{"id":"calcipotriene-betamethasone-gel-and-ointment","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or burning at application site"},{"rate":null,"effect":"Hypercalcemia (with systemic absorption)"},{"rate":null,"effect":"Local atrophy or striae (corticosteroid-related)"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":{"chemblId":"CHEMBL1697784","moleculeType":"Small molecule","molecularWeight":"504.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriene acts as a vitamin D receptor agonist, normalizing keratinocyte differentiation and reducing hyperproliferation characteristic of psoriasis. Betamethasone dipropionate is a potent topical corticosteroid that suppresses inflammatory cytokines and immune cell infiltration. The combination provides synergistic anti-inflammatory and anti-proliferative effects on psoriatic plaques.","oneSentence":"Calcipotriene (a vitamin D analog) reduces skin cell proliferation and promotes differentiation, while betamethasone (a corticosteroid) suppresses inflammation and immune response in psoriatic skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:59.190Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis"},{"name":"Psoriatic dermatitis"}]},"trialDetails":[{"nctId":"NCT00670241","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel Compared With Tacalcitol Ointment and the Gel Vehicle Alone in Patients With Psoriasis Vulgaris","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-04","conditions":"Psoriasis Vulgaris","enrollment":458},{"nctId":"NCT02668692","phase":"PHASE3","title":"LEO 80185 Gel (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-02","conditions":"Psoriasis Vulgaris","enrollment":213},{"nctId":"NCT00279162","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriene/Betamethasone Gel/Ointment in Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2005-12","conditions":"Psoriasis","enrollment":160},{"nctId":"NCT02999776","phase":"PHASE1","title":"Laser-assisted Topical Administration of Etanercept (Enbrel®) in Patients With Mild to Moderate Plaque-type Psoriasis","status":"UNKNOWN","sponsor":"Pantec Biosolutions AG","startDate":"2016-11","conditions":"Psoriatic Plaque","enrollment":30},{"nctId":"NCT01413477","phase":"NA","title":"Nickel Desensitization Using Topical Therapy","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2011-08","conditions":"Allergic Contact Dermatitis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Calcipotriene/betamethasone gel and ointment","genericName":"Calcipotriene/betamethasone gel and ointment","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcipotriene (a vitamin D analog) reduces skin cell proliferation and promotes differentiation, while betamethasone (a corticosteroid) suppresses inflammation and immune response in psoriatic skin. Used for Plaque psoriasis, Psoriatic dermatitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}