{"id":"caiv-t","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal congestion"},{"rate":null,"effect":"Runny nose"},{"rate":null,"effect":"Sore throat"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL1697734","moleculeType":"Small molecule","molecularWeight":"227.65"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CAIV-T (Cold-Adapted Influenza Vaccine - Trivalent) uses temperature-sensitive, live attenuated influenza virus strains that replicate efficiently in the cooler upper respiratory tract but are restricted in replication in warmer lower respiratory and systemic tissues. This approach induces both local mucosal immunity (IgA) and systemic immunity (IgG), providing broader and more durable protection compared to inactivated vaccines. The vaccine covers influenza A (H1N1 and H3N2) and influenza B strains.","oneSentence":"CAIV-T is a live attenuated influenza vaccine administered intranasally that stimulates mucosal and systemic immune responses against influenza A and B viruses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:37.152Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seasonal influenza prevention in children and adults"}]},"trialDetails":[{"nctId":"NCT00192387","phase":"PHASE2","title":"Trial to Investigate Viral Shedding in Healthy Children Vaccinated With Vaccine Virus Liquid (CAIV-T)","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2001-09","conditions":"Influenza","enrollment":60},{"nctId":"NCT00192192","phase":"PHASE3","title":"Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold Adapted (CAIV-T) in Healthy Adults","status":"COMPLETED","sponsor":"MedImmune 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