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The long-acting injectable formulation allows for monthly or bimonthly dosing, improving adherence compared to daily oral therapy.","oneSentence":"CAB + RPV is a long-acting injectable combination of cabotegravir (an integrase inhibitor) and rilpivirine (a non-nucleoside reverse transcriptase inhibitor) that suppresses HIV replication by blocking two critical steps in the viral life cycle.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:34.180Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection in treatment-experienced adults as maintenance therapy"},{"name":"HIV-1 infection in treatment-naive adults as maintenance therapy"}]},"trialDetails":[{"nctId":"NCT02938520","phase":"PHASE3","title":"Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive 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