{"id":"c16g2-varnish","_chembl":{"chemblId":"CHEMBL4297712","moleculeType":"Unknown"},"modality":"Small molecule","_dailymed":null,"mechanism":{"explanation":"The varnish formulation is applied topically to tooth surfaces where it works to reduce populations of bacteria responsible for dental caries. The specific molecular mechanism and bacterial targets have not been publicly disclosed.","oneSentence":"C16G2 Varnish is designed to selectively target and eliminate cariogenic bacteria in the oral cavity."},"_scrapedAt":"2026-03-28T03:25:25.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123212,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Fluoride varnish","brand":"Duraphat","company":"Colgate","rationale":"Standard of care topical fluoride for caries prevention"},{"name":"Silver diamine fluoride","brand":"Advantage Arrest","company":"Elevate Oral Care","rationale":"Antimicrobial agent for arresting dental caries"},{"name":"Chlorhexidine varnish","brand":"Cervitec","company":"Ivoclar Vivadent","rationale":"Antimicrobial varnish targeting cariogenic bacteria"}],"description":"C16G2 Varnish is an investigational antimicrobial therapy developed by Armata Pharmaceuticals for the prevention of dental caries. The varnish formulation is designed to target and reduce oral bacteria associated with tooth decay, representing a novel approach to cavity prevention in dental care.","indications":{"approved":[{"status":"investigational","condition":"Dental caries prevention","patientPopulation":"Pediatric and adult populations at risk for cavities"}]},"trialDetails":[{"nctId":"NCT03004365","phase":"PHASE2","title":"A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects","status":"COMPLETED","sponsor":"Armata Pharmaceuticals, Inc.","startDate":"2017-01-27","conditions":"Dental Caries","enrollment":33},{"nctId":"NCT03196219","phase":"PHASE2","title":"A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects","status":"COMPLETED","sponsor":"Armata Pharmaceuticals, Inc.","startDate":"2017-07-07","conditions":"Dental Caries","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"C16G2 Varnish","genericName":"C16G2 Varnish","companyName":"Armata Pharmaceuticals, Inc.","companyId":"armata-pharmaceuticals-inc","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}