{"id":"c1-inhibitor-human-c1-inh","safety":{"commonSideEffects":[{"rate":null,"effect":"Thrombosis / Thromboembolic events"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":{"setId":"d53a911f-070d-498a-8a61-baab72b9d0fe","title":"CINRYZE (HUMAN C1-ESTERASE INHIBITOR) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION CINRYZE (HUMAN C1-ESTERASE INHIBITOR) KIT [TAKEDA PHARMACEUTICALS AMERICA, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"C1 INH is a serine protease inhibitor that controls activation of the complement system's classical pathway by binding to and inactivating C1s. By suppressing this early cascade step, it prevents excessive generation of inflammatory mediators (C3a, C5a) and bradykinin, thereby reducing pathological inflammation and angioedema. This mechanism is particularly relevant in hereditary angioedema (HAE), where C1 INH deficiency or dysfunction leads to uncontrolled complement and contact system activation.","oneSentence":"C1 inhibitor (human) is a plasma protein that regulates the initial step of the classical complement cascade by inhibiting C1s protease activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:07.708Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hereditary angioedema (HAE) — acute attack treatment"},{"name":"Hereditary angioedema (HAE) — prophylaxis of recurrent attacks"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CINRYZE","C1 esterase inhibitor (human)"],"phase":"marketed","status":"active","brandName":"C1 inhibitor (human) [C1 INH]","genericName":"C1 inhibitor (human) [C1 INH]","companyName":"Shire","companyId":"shire","modality":"Biologic","firstApprovalDate":"","aiSummary":"C1 inhibitor (human) is a plasma protein that regulates the initial step of the classical complement cascade by inhibiting C1s protease activity. Used for Hereditary angioedema (HAE) — acute attack treatment, Hereditary angioedema (HAE) — prophylaxis of recurrent attacks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}