{"id":"c-propionate-corticosteroid-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Systemic corticosteroid absorption effects (with prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobetasol propionate is a Class I (super-potent) topical corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators and reduced immune cell infiltration. It is used to treat severe inflammatory skin conditions where rapid anti-inflammatory and immunosuppressive effects are needed.","oneSentence":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:37.094Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)"}]},"trialDetails":[{"nctId":"NCT02232087","phase":"PHASE1","title":"Single Blind Cross-over Dose Response Study in Subjects of Two Inhalers of Salmeterol and Fluticasone Propionate","status":"COMPLETED","sponsor":"Kindeva Drug Delivery","startDate":"2014-07","conditions":"Healthy","enrollment":52},{"nctId":"NCT00438399","phase":"PHASE3","title":"Subject Preference for Scalp Psoriasis Treatment","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-02","conditions":"Scalp Psoriasis","enrollment":219}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CP Shampoo compared to Corticosteroid 2"],"phase":"phase_3","status":"active","brandName":"C. propionate- Corticosteroid 2","genericName":"C. propionate- Corticosteroid 2","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}