{"id":"c-difficile-vaccine-formulation-1","safety":{"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Antacids","action":"Avoid","effect":"Reduced efficacy of vaccine"},{"drug":"Proton pump inhibitors","action":"Avoid","effect":"Reduced efficacy of vaccine"},{"drug":"H2 blockers","action":"Avoid","effect":"Reduced efficacy of vaccine"},{"drug":"Immunosuppressants","action":"Monitor","effect":"Reduced immune response"},{"drug":"Live vaccines","action":"Avoid","effect":"Interference with immune response"},{"drug":"Bacillus Calmette-Guérin (BCG) vaccine","action":"Avoid","effect":"Interference with immune response"},{"drug":"Typhoid vaccine","action":"Avoid","effect":"Interference with immune response"}],"contraindications":["Hypersensitivity to any component of the vaccine","Severe acute illness","Moderate to severe acute gastroenteritis","Immunocompromised individuals","Pregnant or breastfeeding women","History of anaphylaxis to a previous dose of the vaccine"]},"_chembl":null,"company":"Pfizer Inc.","_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=c-difficile-vaccine-formulation-1","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:56:01.777809+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-19T23:56:17.608708+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:56:08.377359+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:56:01.850310+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=c-difficile-vaccine-formulation-1","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:56:08.689558+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108795/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:56:10.090867+00:00"}},"allNames":"c. difficile vaccine formulation 1.","timeline":[],"_dailymed":null,"aiSummary":"C. difficile vaccine formulation 1 is being studied in a clinical trial (NCT05805826) for its safety and effects in healthy adults. 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Further research is needed to fully understand the vaccine's mechanism of action."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"_scrapedAt":"2026-03-27T23:28:57.650Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"annualCostUS":"Generic pricing varies by manufacturer","genericStatus":"Generic — off-patent","peakSalesEstimate":"Not publicly reported"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=c-difficile-vaccine-formulation-1","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=c-difficile-vaccine-formulation-1","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":4,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":5,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:56:17.608797+00:00","fieldsConflicting":1,"overallConfidence":0.8},"_whoChecked":true,"competitors":[{"name":"Vibativ","company":"Theravance Biopharma","advantage":"Longer duration of action compared to C. difficile vaccine formulation 1","genericName":"telavancin"},{"name":"Zinforo","company":"Pfizer","advantage":"Broader spectrum of activity against Gram-positive bacteria","genericName":"ceftaroline fosamil"},{"name":"Cefepime","company":"Bristol Myers Squibb","advantage":"More stable in acidic environments, allowing for oral administration","genericName":"cefepime"}],"genericName":"c-difficile-vaccine-formulation-1","indications":{"approved":[{"name":"Prevention of Clostridioides difficile infection in individuals 50 years of age and older","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_mhraChecked":true,"trialDetails":[{"nctId":"NCT05805826","phase":"PHASE1, PHASE2","title":"To Understand the Safety and Effects of a C. 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