{"id":"c-11-labeled-nicotine","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a research imaging agent, not a therapeutic drug. The carbon-11 radiolabel enables PET imaging to map nicotinic acetylcholine receptor availability and occupancy in vivo. It is used to study receptor pharmacology, disease pathology, and drug engagement in conditions affecting cholinergic neurotransmission.","oneSentence":"C-11 labeled nicotine is a radiotracer that binds to nicotinic acetylcholine receptors and allows visualization of receptor distribution and density in the brain using positron emission tomography (PET) imaging.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:29:12.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Research imaging of nicotinic acetylcholine receptor distribution and occupancy in the brain"},{"name":"Investigation of neuropsychiatric and neurodegenerative disorders involving cholinergic dysfunction"}]},"trialDetails":[{"nctId":"NCT03491059","phase":"PHASE4","title":"Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use","status":"UNKNOWN","sponsor":"University of Cincinnati","startDate":"2018-02-16","conditions":"E-cigarette Use","enrollment":2}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"C-11 labeled nicotine","genericName":"C-11 labeled nicotine","companyName":"University of Cincinnati","companyId":"university-of-cincinnati","modality":"Small molecule","firstApprovalDate":"","aiSummary":"C-11 labeled nicotine is a radiotracer that binds to nicotinic acetylcholine receptors and allows visualization of receptor distribution and density in the brain using positron emission tomography (PET) imaging. Used for Research imaging of nicotinic acetylcholine receptor distribution and occupancy in the brain, Investigation of neuropsychiatric and neurodegenerative disorders involving cholinergic dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}