{"id":"butyrate-enemas-routine-management","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Rectal irritation"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Butyrate is a short-chain fatty acid that serves as a primary fuel source for colonocytes and enhances intestinal barrier function. It reduces inflammatory cytokine production, increases tight junction proteins, and promotes the growth of beneficial commensal bacteria. When administered as an enema in combination with standard medical management, it aims to improve mucosal healing and reduce disease activity in inflammatory bowel conditions.","oneSentence":"Butyrate enemas deliver short-chain fatty acids directly to the colon to reduce inflammation and promote healing of the intestinal mucosa.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:36.059Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ulcerative colitis (adjunctive therapy with routine management)"}]},"trialDetails":[{"nctId":"NCT03660176","phase":"PHASE3","title":"Effects of Butyrate Enemas on Postoperative Intestinal Mobility Disorders in Hirschsprung's Disease","status":"UNKNOWN","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2019-01-02","conditions":"Hirschsprung's Disease","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"butyrate enemas + routine management","genericName":"butyrate enemas + routine management","companyName":"Assistance Publique Hopitaux De Marseille","companyId":"assistance-publique-hopitaux-de-marseille","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butyrate enemas deliver short-chain fatty acids directly to the colon to reduce inflammation and promote healing of the intestinal mucosa. Used for Ulcerative colitis (adjunctive therapy with routine management).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}