{"id":"butropium","rwe":[{"pmid":"3449985","year":"1987","title":"Endoscopic manometry of the sphincter of Oddi in dogs. Pharmacological effects of anticholinergic and selective antimuscarinic agents.","finding":"","journal":"The Tokai journal of experimental and clinical medicine","studyType":"Clinical Study"},{"pmid":"3478945","year":"1987","title":"Sensation of aural fullness and its treatment with an autonomic nerve blocking agent.","finding":"","journal":"Acta oto-laryngologica. Supplementum","studyType":"Clinical Study"},{"pmid":"4084348","year":"1985","title":"Effect of glucagon on gastric motility examined by the acetaminophen absorption method and the endoscopic procedure.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"7182948","year":"1982","title":"Gastric emptying in patients with gastric ulcers--effects of oral and intramuscular administration of anticholinergic drug.","finding":"","journal":"The Tokai journal of experimental and clinical medicine","studyType":"Clinical Study"},{"pmid":"7431672","year":"1980","title":"Effect of N-(4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation.","finding":"","journal":"Japanese heart journal","studyType":"Clinical Study"}],"tags":[{"label":"butropium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Gastritis","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"coliopan","offLabel":[],"synonyms":["butropium","butropium bromide","coliopan"],"timeline":[],"brandName":"Coliopan","ecosystem":[{"indication":"Gastritis","otherDrugs":[],"globalPrevalence":159000000}],"mechanism":{"modality":"Small Molecule","drugClass":"butropium","explanation":"Imagine your stomach has a 'brake' and an 'accelerator' system. The brake system helps to slow down acid production, while the accelerator system speeds it up. Coliopan works by pressing the brake pedal, reducing acid production and helping to soothe the stomach lining.","oneSentence":"Coliopan works by blocking muscarinic acetylcholine receptors in the stomach, reducing acid production and inflammation.","technicalDetail":"Coliopan exerts its effects by competitively antagonizing muscarinic acetylcholine receptors, specifically M1, M2, and M3 subtypes, which are involved in the regulation of gastric acid secretion and smooth muscle contraction."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/456","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTROPIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:06:04.366916","biosimilars":[],"competitors":[],"genericName":"butropium","indications":{"approved":[{"name":"Gastritis","source":"DrugCentral","snomedId":4556007,"regulator":"FDA","usPrevalence":null,"globalPrevalence":159000000,"prevalenceMethod":"curated","prevalenceSource":"Microb Pathog, 2022 (PMID:35405277)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010874","UNII":"7WSK03KXXW","CHEBI":"CHEBI:31327","INN_ID":"3498","UMLSCUI":"C1613444","ChEMBL_ID":"CHEMBL2110820","KEGG_DRUG":"D01491","DRUGBANK_ID":"DB15968","PUBCHEM_CID":"656593","SECONDARY_CAS_RN":"107080-63-7"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1987 May","pmid":"3449985","title":"Endoscopic manometry of the sphincter of Oddi in dogs. Pharmacological effects of anticholinergic and selective antimuscarinic agents.","journal":"The Tokai journal of experimental and clinical medicine"},{"date":"1987","pmid":"3478945","title":"Sensation of aural fullness and its treatment with an autonomic nerve blocking agent.","journal":"Acta oto-laryngologica. Supplementum"},{"date":"1985","pmid":"4084348","title":"Effect of glucagon on gastric motility examined by the acetaminophen absorption method and the endoscopic procedure.","journal":"Arzneimittel-Forschung"},{"date":"1982 Sep","pmid":"7182948","title":"Gastric emptying in patients with gastric ulcers--effects of oral and intramuscular administration of anticholinergic drug.","journal":"The Tokai journal of experimental and clinical medicine"},{"date":"1980 Sep","pmid":"7431672","title":"Effect of N-(4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation.","journal":"Japanese heart journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Coliopan is a small molecule medication with the chemical name butropium bromide. It is also known by other names, including butropium bromide, bromure de butropium, bromuro de butropio, and butropium bromide.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}