{"id":"butriptyline","rwe":[{"pmid":"34389045","year":"2021","title":"Tricyclic antidepressants versus 'active placebo', placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis.","finding":"","journal":"Systematic reviews","studyType":"Clinical Study"},{"pmid":"34034811","year":"2021","title":"Beneficial and harmful effects of antidepressants versus placebo, 'active placebo', or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses.","finding":"","journal":"Systematic reviews","studyType":"Clinical Study"},{"pmid":"7967544","year":"1994","title":"Concentrations of butriptyline in biological fluids following a fatal overdose.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"},{"pmid":"3592617","year":"1987","title":"Screening of drugs for thermogenic anti-obesity properties: antidepressants.","finding":"","journal":"Annals of nutrition & metabolism","studyType":"Clinical Study"},{"pmid":"2868091","year":"1985","title":"Photon correlation spectroscopy of surface active cationic drugs.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"butriptyline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sodium-dependent serotonin transporter","category":"target"},{"label":"SLC6A4","category":"gene"},{"label":"SLC6A3","category":"gene"},{"label":"SLC6A2","category":"gene"},{"label":"N06AA15","category":"atc"},{"label":"Active","category":"status"},{"label":"Depressive disorder","category":"indication"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Antidepressive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butriptylene","offLabel":[],"synonyms":["butriptyline hydrochloride","butriptyline","butriptylene","butriptyline HCl"],"timeline":[],"brandName":"Butriptylene","ecosystem":[{"indication":"Depressive disorder","otherDrugs":[{"name":"amitriptyline","slug":"amitriptyline","company":"Astrazeneca"},{"name":"amoxapine","slug":"amoxapine","company":"Lederle"},{"name":"bupropion","slug":"bupropion","company":"Glaxosmithkline"},{"name":"citalopram","slug":"citalopram","company":"Forest Labs"}],"globalPrevalence":280000000}],"mechanism":{"target":"Sodium-dependent serotonin transporter","targets":[{"gene":"SLC6A4","source":"DrugCentral","target":"Sodium-dependent serotonin transporter","protein":"Sodium-dependent serotonin transporter"},{"gene":"SLC6A3","source":"DrugCentral","target":"Sodium-dependent dopamine transporter","protein":"Sodium-dependent dopamine transporter"},{"gene":"SLC6A2","source":"DrugCentral","target":"Sodium-dependent noradrenaline transporter","protein":"Sodium-dependent noradrenaline transporter"}],"modality":"Small Molecule","drugClass":"butriptyline","explanation":"Think of serotonin like a messenger that helps regulate your mood. When serotonin is released, it sends a signal to other parts of the brain. Butriptyline helps keep these messengers in the brain longer by blocking their reabsorption, which can help improve mood and reduce symptoms of depression.","oneSentence":"Butriptyline works by blocking the reuptake of serotonin, a neurotransmitter involved in mood regulation, allowing more serotonin to be available in the brain.","technicalDetail":"Butriptyline acts as a selective serotonin reuptake inhibitor (SSRI) by binding to the sodium-dependent serotonin transporter (SERT), preventing the reuptake of serotonin and increasing its concentration in the synaptic 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It is also known by several synonyms, including butriptyline and evadene.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}