{"id":"butofilolol","rwe":[{"pmid":"6151828","year":"1984","title":"[Changes in sweating during exertion. Effects of beta-blocker treatment].","finding":"","journal":"Archives des maladies du coeur et des vaisseaux","studyType":"Clinical Study"},{"pmid":"6148036","year":"1984","title":"[Evaluation of the acute hemodynamic effects of butofilolol in the arterial hypertensive patient. Comparison with propranolol and atenolol].","finding":"","journal":"Annales de cardiologie et d'angeiologie","studyType":"Clinical Study"},{"pmid":"6149195","year":"1984","title":"Pharmacokinetics of butofilolol (CAFIDE) after repeated oral administration in man.","finding":"","journal":"International journal of clinical pharmacology research","studyType":"Clinical Study"},{"pmid":"6149194","year":"1984","title":"Butofilolol pharmacokinetics in chronic renal insufficiency.","finding":"","journal":"International journal of clinical pharmacology research","studyType":"Clinical Study"},{"pmid":"6668311","year":"1983","title":"Comparison of gas chromatographic--electron-capture detection and high-performance liquid chromatography for the determination of butofilolol in biological fluids.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"butofilolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["butofilolol"],"offLabel":[],"synonyms":["butofilolol"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butofilolol","explanation":"Imagine your body's cells have locks on them, and BUTOFILOLOL is a key that fits into those locks. By blocking these locks, BUTOFILOLOL can prevent certain chemical signals from being sent, which can help to treat various conditions. However, the exact locks and signals it targets are still unknown.","oneSentence":"BUTOFILOLOL is thought to work by blocking certain receptors in the body to produce its therapeutic effects.","technicalDetail":"BUTOFILOLOL is a beta-adrenergic receptor blocker, specifically targeting beta-1 and beta-2 adrenergic receptors, although the exact receptor subtype specificity is unclear."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/453","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTOFILOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:06:56.017638","biosimilars":[],"competitors":[],"genericName":"butofilolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4AZC6Y5A8G","INN_ID":"4459","UMLSCUI":"C0054262","ChEMBL_ID":"CHEMBL157443","PUBCHEM_CID":"68838","MESH_SUPPLEMENTAL_RECORD_UI":"C036631"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1984 Oct","pmid":"6151828","title":"[Changes in sweating during exertion. Effects of beta-blocker treatment].","journal":"Archives des maladies du coeur et des vaisseaux"},{"date":"1984 Jul-Sep","pmid":"6148036","title":"[Evaluation of the acute hemodynamic effects of butofilolol in the arterial hypertensive patient. Comparison with propranolol and atenolol].","journal":"Annales de cardiologie et d'angeiologie"},{"date":"1984","pmid":"6149195","title":"Pharmacokinetics of butofilolol (CAFIDE) after repeated oral administration in man.","journal":"International journal of clinical pharmacology research"},{"date":"1984","pmid":"6149194","title":"Butofilolol pharmacokinetics in chronic renal insufficiency.","journal":"International journal of clinical pharmacology research"},{"date":"1983 Dec 9","pmid":"6668311","title":"Comparison of gas chromatographic--electron-capture detection and high-performance liquid chromatography for the determination of butofilolol in biological fluids.","journal":"Journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"BUTOFILOLOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BUTOFILOLOL is a small molecule drug in the butofilolol class, but its original developer and current owner are unknown. Its target and exact mechanism of action are also unclear. BUTOFILOLOL is not FDA-approved for any indications, and its commercial status, half-life, bioavailability, and generic manufacturers are unknown. As a result, there is limited information available on its safety profile and potential side effects. Further research is needed to fully understand this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}