{"id":"butoctamide","rwe":[{"pmid":"7624490","year":"1995","title":"Stimulatory effect of butoctamide hydrogen succinate on REM sleep in normal humans.","finding":"","journal":"Progress in neuro-psychopharmacology & biological psychiatry","studyType":"Clinical Study"},{"pmid":"7604145","year":"1995","title":"Long-term administration of butoctamide hydrogen succinate on nocturnal sleep of mentally retarded subjects: a polygraphic study versus placebo.","finding":"","journal":"Psychopharmacology","studyType":"Clinical Study"},{"pmid":"2497487","year":"1989","title":"Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers.","finding":"","journal":"Psychopharmacology","studyType":"Clinical Study"},{"pmid":"3449033","year":"1987","title":"[Dependence study on butoctamide hydrogen succinate (M-2H) in rhesus monkeys].","finding":"","journal":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","studyType":"Clinical Study"},{"pmid":"2963363","year":"1987","title":"Butoctamide hydrogen succinate and intensive learning sessions: effects on night sleep of Down's syndrome patients.","finding":"","journal":"Sleep","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hexobutyramide","offLabel":[],"synonyms":["butoctamide semisuccinate","butoctamide","hexobutyramide"],"timeline":[],"brandName":"Hexobutyramide","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like a orchestra, and each cell has its own specific role to play. Hexobutyramide is like a conductor that helps the cells work together in harmony by binding to and modulating the activity of specific molecules. This helps to restore balance and normal function to the cells and tissues.","oneSentence":"Hexobutyramide works by binding to and modulating the activity of specific biological molecules to produce a therapeutic effect.","technicalDetail":"Hexobutyramide is a small molecule that likely interacts with specific receptors or enzymes to produce its therapeutic effect, although the exact mechanism of action is currently unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/451","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTOCTAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:09:47.539773","biosimilars":[],"competitors":[],"genericName":"butoctamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"6MDC25LQSR","CHEBI":"CHEBI:31326","INN_ID":"3989","UMLSCUI":"C0054260","ChEMBL_ID":"CHEMBL452859","KEGG_DRUG":"D01498","PUBCHEM_CID":"65780","SECONDARY_CAS_RN":"32838-28-1","MESH_SUPPLEMENTAL_RECORD_UI":"C013857"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1995 May","pmid":"7624490","title":"Stimulatory effect of butoctamide hydrogen succinate on REM sleep in normal humans.","journal":"Progress in neuro-psychopharmacology & biological psychiatry"},{"date":"1995 Feb","pmid":"7604145","title":"Long-term administration of butoctamide hydrogen succinate on nocturnal sleep of mentally retarded subjects: a polygraphic study versus placebo.","journal":"Psychopharmacology"},{"date":"1989","pmid":"2497487","title":"Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers.","journal":"Psychopharmacology"},{"date":"1987 Dec","pmid":"3449033","title":"[Dependence study on butoctamide hydrogen succinate (M-2H) in rhesus monkeys].","journal":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence"},{"date":"1987 Dec","pmid":"2963363","title":"Butoctamide hydrogen succinate and intensive learning sessions: effects on night sleep of Down's syndrome patients.","journal":"Sleep"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hexobutyramide is a small molecule. It is also known by the synonyms butoctamide and butoctamida.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}