{"id":"butizide","rwe":[{"pmid":"16044110","year":"2005","title":"Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.","finding":"","journal":"Therapeutic drug monitoring","studyType":"Clinical Study"},{"pmid":"12147042","year":"2002","title":"Phototoxicity to diuretics and antidiabetics in the cultured keratinocyte cell line HaCaT: evaluation by clonogenic assay and single cell gel electrophoresis Comet assay).","finding":"","journal":"Photodermatology, photoimmunology & photomedicine","studyType":"Clinical Study"},{"pmid":"9342417","year":"1997","title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"9303564","year":"1997","title":"Cell cultures in the investigation of thiazide phototoxicity.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"9134756","year":"1997","title":"Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.","finding":"","journal":"Journal of photochemistry and photobiology. B, Biology","studyType":"Clinical Study"}],"tags":[{"label":"butizide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03EA14","category":"atc"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Diuretics","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butizid","offLabel":[],"synonyms":["butizide","buthiazide","butizid","isobutylhydrochlorothiazide","thiabutazide"],"timeline":[],"brandName":"Butizid","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butizide","explanation":"Imagine your kidneys as filters that remove waste and excess fluids from your blood. Butizide helps these filters work more efficiently by blocking the reabsorption of sodium and chloride, which are essential for maintaining fluid balance in the body. This leads to increased urine production, which can help to remove excess fluids and waste products.","oneSentence":"Butizide is thought to work by inhibiting the reabsorption of sodium and chloride ions in the kidneys, leading to increased urine production.","technicalDetail":"Butizide is believed to act as a loop diuretic, inhibiting the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, leading to increased sodium and chloride excretion and subsequent diuresis."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Butizide","title":"Butizide","extract":"Butizide is a diuretic of the thiazide class."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/446","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=butizide","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=butizide","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Butizide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:05:36.064544","biosimilars":[],"competitors":[{"drugName":"hydrochlorothiazide","drugSlug":"hydrochlorothiazide","fdaApproval":"1959-02-12","patentExpiry":"Jan 23, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"trichlormethiazide","drugSlug":"trichlormethiazide","fdaApproval":"1960-03-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bendroflumethiazide","drugSlug":"bendroflumethiazide","fdaApproval":"1959-12-07","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"butizide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrochlorothiazide","brandName":"hydrochlorothiazide","genericName":"hydrochlorothiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"trichlormethiazide","brandName":"trichlormethiazide","genericName":"trichlormethiazide","approvalYear":"1960","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"bendroflumethiazide","brandName":"bendroflumethiazide","genericName":"bendroflumethiazide","approvalYear":"1959","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04465123","phase":"PHASE3","title":"Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study","status":"UNKNOWN","sponsor":"Chiang Mai University","startDate":"2020-08-13","conditions":["Acute Heart Failure","Acute Kidney Injury"],"enrollment":100,"completionDate":"2022-12-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004333","UNII":"W00SSD35VW","CHEBI":"CHEBI:135492","INN_ID":"1410","RXNORM":"19882","UMLSCUI":"C0054257","ChEMBL_ID":"CHEMBL2104197","KEGG_DRUG":"D03189","DRUGBANK_ID":"DB15861","PUBCHEM_CID":"16274","SNOMEDCT_US":"20551000122108","MESH_SUPPLEMENTAL_RECORD_UI":"C009732"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Nephrology"],"atcClassification":{"source":"DrugCentral","atcCode":"C03EA14","allCodes":["C03EA14"]},"biosimilarFilings":[],"recentPublications":[{"date":"2005 Aug","pmid":"16044110","title":"Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.","journal":"Therapeutic drug monitoring"},{"date":"2002 Apr","pmid":"12147042","title":"Phototoxicity to diuretics and antidiabetics in the cultured keratinocyte cell line HaCaT: evaluation by clonogenic assay and single cell gel electrophoresis Comet assay).","journal":"Photodermatology, photoimmunology & photomedicine"},{"date":"1997 Sep","pmid":"9342417","title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.","journal":"Arzneimittel-Forschung"},{"date":"1997 Sep","pmid":"9303564","title":"Cell cultures in the investigation of thiazide phototoxicity.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"1997 Mar","pmid":"9134756","title":"Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.","journal":"Journal of photochemistry and photobiology. B, Biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Butizide is a small molecule diuretic of the thiazide class. It is also known by various synonyms, including BUTHIAZIDE, BUTIZIDA, BUTIZIDE, and ISOBUTYLHYDROCHLOROTHIAZIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}