{"id":"butibufen","rwe":[],"tags":[{"label":"butibufen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["butibufen","butibufen sodium"],"offLabel":[],"synonyms":["butibufen","butibufen sodium"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butibufen","explanation":"Think of it like a phone line - butibufen is like a switch that disconnects the line, preventing pain signals from reaching the brain. This can help reduce pain and discomfort. By blocking these enzymes, butibufen can help alleviate pain without affecting other bodily functions.","oneSentence":"Butibufen works by blocking enzymes that transmit pain signals to the brain.","technicalDetail":"Butibufen is a non-selective inhibitor of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins that mediate pain and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/447","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTIBUFEN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:05:31.717004","biosimilars":[],"competitors":[],"genericName":"butibufen","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004196","UNII":"JSS1TEM917","CHEBI":"CHEBI:134908","INN_ID":"3657","RXNORM":"19880","UMLSCUI":"C0054255","ChEMBL_ID":"CHEMBL454450","PUBCHEM_CID":"41643","SECONDARY_CAS_RN":"60682-24-8","MESH_SUPPLEMENTAL_RECORD_UI":"C012797"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"BUTIBUFEN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butibufen is a small molecule with the chemical name 2-(P-ISOBUTYLPHENYL)BUTYRIC ACID. It is also known by the synonyms butibufen and butibuferene.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}