{"id":"butenafine-hcl-1-bay1896425","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Local irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL1200397","moleculeType":"Small molecule","molecularWeight":"353.94"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Butenafine inhibits the fungal enzyme squalene epoxidase, which is critical for ergosterol synthesis in the fungal cell membrane. This causes accumulation of squalene and depletion of ergosterol, destabilizing the fungal cell membrane and resulting in fungal cell death. It is effective against dermatophytes, yeasts, and other fungi causing topical infections.","oneSentence":"Butenafine HCl is an allylamine antifungal that disrupts fungal cell membrane integrity by inhibiting squalene epoxidase, leading to ergosterol depletion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:31.349Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal skin infections (dermatophytosis, tinea pedis, tinea corporis, tinea cruris)"}]},"trialDetails":[{"nctId":"NCT04531540","phase":"PHASE3","title":"Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)","status":"COMPLETED","sponsor":"Bayer","startDate":"2013-09-09","conditions":"Hypersensitivity","enrollment":225},{"nctId":"NCT04532164","phase":"PHASE3","title":"Study to Find Out if Cream V61-044 Used to Treat Fungal Infections Causes an Allergic Skin Reaction to Sunlight in Healthy Participants","status":"COMPLETED","sponsor":"Bayer","startDate":"2013-06-10","conditions":"Dermatitis, Photoallergic","enrollment":137},{"nctId":"NCT04531527","phase":"PHASE3","title":"Study to Learn More About the Potential of Antifungal Cream V61-044 Containing Trolamine to Cause Irritant Reaction of the Skin to Ultra Violet Light in Healthy Human Subjects","status":"COMPLETED","sponsor":"Bayer","startDate":"2013-06-24","conditions":"Dermatitis, Phototoxic","enrollment":32},{"nctId":"NCT04531813","phase":"PHASE3","title":"Study to Determine Skin Irritation Potential of an Antifungal Cream Containing Trolamine After Repeated Skin Application (Cumulative Irritation Patch Test)","status":"COMPLETED","sponsor":"Bayer","startDate":"2013-06-10","conditions":"Hypersensitivity","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Antifungal Cream V61-044 containing Trolamine"],"phase":"phase_3","status":"active","brandName":"Butenafine HCl 1% (BAY1896425)","genericName":"Butenafine HCl 1% (BAY1896425)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butenafine HCl is an allylamine antifungal that disrupts fungal cell membrane integrity by inhibiting squalene epoxidase, leading to ergosterol depletion. Used for Fungal skin infections (dermatophytosis, tinea pedis, tinea corporis, tinea cruris).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}