{"id":"butaperazine","rwe":[{"pmid":"41471088","year":"2025","title":"Towards Explainable Computational Toxicology: Linking Antitargets to Rodent Acute Toxicity.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"24766970","year":"2014","title":"Chlorpromazine versus every other antipsychotic for schizophrenia: a systematic review and meta-analysis challenging the dogma of equal efficacy of antipsychotic drugs.","finding":"","journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","studyType":"Clinical Study"},{"pmid":"11874120","year":"2002","title":"Spectrophotometric determination of cerium(IV) using a phenothiazine derivative.","finding":"","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry","studyType":"Clinical Study"},{"pmid":"11708104","year":"2001","title":"Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives.","finding":"","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry","studyType":"Clinical Study"},{"pmid":"1784614","year":"1991","title":"[Automatic, electronic determination of resting time in small laboratory animals and the effect of psychopharmaceuticals].","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"}],"tags":[{"label":"butaperazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05AB09","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"emerex","offLabel":[],"synonyms":["butaperazine","butyrylperazine","emerex","megalectil","randolectil"],"timeline":[],"brandName":"Emerex","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butaperazine","explanation":"Think of dopamine as a messenger in the brain that helps us feel pleasure and motivation. When there's too much dopamine, it can lead to symptoms like anxiety, agitation, and hallucinations. Butaperazine helps to calm the brain by blocking these dopamine receptors, which can bring relief from these symptoms.","oneSentence":"Butaperazine works by blocking dopamine receptors in the brain, which can help to reduce symptoms of certain psychiatric conditions.","technicalDetail":"Butaperazine is a dopamine D2 receptor antagonist, which means it binds to and blocks the action of dopamine at these receptors, leading to a decrease in dopamine-mediated neurotransmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/443","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTAPERAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:05:19.570878","biosimilars":[],"competitors":[{"drugName":"fluphenazine","drugSlug":"fluphenazine","fdaApproval":"1959-09-09","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"perphenazine","drugSlug":"perphenazine","fdaApproval":"1957-02-27","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"prochlorperazine","drugSlug":"prochlorperazine","fdaApproval":"1956-10-23","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"trifluoperazine","drugSlug":"trifluoperazine","fdaApproval":"1959-04-16","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acetophenazine","drugSlug":"acetophenazine","fdaApproval":"1961-04-05","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"butaperazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"fluphenazine","brandName":"fluphenazine","genericName":"fluphenazine","approvalYear":"1959","relationship":"same-class"},{"drugId":"perphenazine","brandName":"perphenazine","genericName":"perphenazine","approvalYear":"1957","relationship":"same-class"},{"drugId":"prochlorperazine","brandName":"prochlorperazine","genericName":"prochlorperazine","approvalYear":"1956","relationship":"same-class"},{"drugId":"trifluoperazine","brandName":"trifluoperazine","genericName":"trifluoperazine","approvalYear":"1959","relationship":"same-class"},{"drugId":"acetophenazine","brandName":"acetophenazine","genericName":"acetophenazine","approvalYear":"1961","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001526","UNII":"TXP4T9106S","CHEBI":"CHEBI:135663","INN_ID":"1432","UMLSCUI":"C0006481","ChEMBL_ID":"CHEMBL1697826","KEGG_DRUG":"D02642","DRUGBANK_ID":"DB13213","PUBCHEM_CID":"12598","SNOMEDCT_US":"75645006","MESH_SUPPLEMENTAL_RECORD_UI":"C084595"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":67,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AB09","allCodes":["N05AB09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec 5","pmid":"41471088","title":"Towards Explainable Computational Toxicology: Linking Antitargets to Rodent Acute Toxicity.","journal":"Pharmaceutics"},{"date":"2014 Jul","pmid":"24766970","title":"Chlorpromazine versus every other antipsychotic for schizophrenia: a systematic review and meta-analysis challenging the dogma of equal efficacy of antipsychotic drugs.","journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology"},{"date":"2002 Feb","pmid":"11874120","title":"Spectrophotometric determination of cerium(IV) using a phenothiazine derivative.","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"},{"date":"2001 Aug","pmid":"11708104","title":"Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives.","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"},{"date":"1991 Jul","pmid":"1784614","title":"[Automatic, electronic determination of resting time in small laboratory animals and the effect of psychopharmaceuticals].","journal":"Die Pharmazie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Emerex, also known as butaperazine, is a small molecule drug in the butaperazine class. Its original development is attributed to an unknown entity, and its current ownership is also unclear. The exact target of butaperazine is unknown, and it has not been approved by the FDA for any indications. Butaperazine is considered off-patent, and its commercial status is likely generic. As a result, key safety considerations and pharmacological details are not well-documented.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}