{"id":"butamirate","rwe":[{"pmid":"38096806","year":"2024","title":"Dendrobium officinale polysaccharides-chemical properties and pharmacodynamic effects on the airways in experimental conditions.","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"34246390","year":"2021","title":"A 72-Year-Old Woman With Multiple Pulmonary Nodules and a History of Malignancy.","finding":"","journal":"Chest","studyType":"Clinical Study"},{"pmid":"33980886","year":"2021","title":"Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"31622270","year":"2019","title":"Analysis of social and medical portrait of children with pertussis, meningococcal infectious, scarlet fever and estimation of their assigned pharmacotherapy.","finding":"","journal":"Wiadomosci lekarskie (Warsaw, Poland : 1960)","studyType":"Clinical Study"},{"pmid":"29938679","year":"2018","title":"Antitussive activity of alcoxyphenyl carbamic acid analogues.","finding":"","journal":"General physiology and biophysics","studyType":"Clinical Study"}],"tags":[{"label":"butamirate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DB13","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butamyrate","offLabel":[],"synonyms":["butamirate citrate","butamyrate citrate","butamirate","butamyrate"],"timeline":[],"brandName":"Butamyrate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butamirate","explanation":"Imagine butamirate as a key that fits into a lock in the body. When it binds to this lock, it can affect how the body works, but we don't yet know exactly how it does this or what it does to help with a particular condition.","oneSentence":"Butamirate is thought to work by interacting with a specific target in the body, although its exact mechanism of action is unknown.","technicalDetail":"Butamirate is a small molecule that binds to a specific target, although the identity of this target is currently unknown. This binding event is thought to trigger a cascade of downstream effects, although the precise molecular mechanisms involved are not well understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/442","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BUTAMIRATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTAMIRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:05:14.750016","biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pentoxyverine","drugSlug":"pentoxyverine","fdaApproval":"","relationship":"same-class"},{"drugName":"clofedanol","drugSlug":"clofedanol","fdaApproval":"","relationship":"same-class"}],"genericName":"butamirate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzonatate","brandName":"benzonatate","genericName":"benzonatate","approvalYear":"1958","relationship":"same-class"},{"drugId":"pentoxyverine","brandName":"pentoxyverine","genericName":"pentoxyverine","approvalYear":"","relationship":"same-class"},{"drugId":"clofedanol","brandName":"clofedanol","genericName":"clofedanol","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05925140","phase":"PHASE1","title":"LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients","status":"UNKNOWN","sponsor":"Lebanese University","startDate":"2020-03-28","conditions":["COVID-19","Hospitalized COVID-19 Patients"],"enrollment":1000,"completionDate":"2025-12-30"},{"nctId":"NCT05182047","phase":"PHASE1","title":"A Study of Butamirate Citrate Syrup Versus (vs) Sinecod Syrup (Vanilla) in Adult Healthy Study Volunteers","status":"WITHDRAWN","sponsor":"McNeil AB","startDate":"2022-03-18","conditions":["Healthy"],"enrollment":0,"completionDate":"2022-05-05"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004305","UNII":"M75MZG2236","CHEBI":"CHEBI:135310","INN_ID":"2704","RXNORM":"19862","UMLSCUI":"C0054236","ChEMBL_ID":"CHEMBL1332546","KEGG_DRUG":"D07594","DRUGBANK_ID":"DB13731","PUBCHEM_CID":"28892","SECONDARY_CAS_RN":"18109-81-4","MESH_SUPPLEMENTAL_RECORD_UI":"C006841"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DB13","allCodes":["R05DB13"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Mar","pmid":"38096806","title":"Dendrobium officinale polysaccharides-chemical properties and pharmacodynamic effects on the airways in experimental conditions.","journal":"Archiv der Pharmazie"},{"date":"2021 Jul","pmid":"34246390","title":"A 72-Year-Old Woman With Multiple Pulmonary Nodules and a History of Malignancy.","journal":"Chest"},{"date":"2021 May 12","pmid":"33980886","title":"Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents.","journal":"Scientific reports"},{"date":"2019","pmid":"31622270","title":"Analysis of social and medical portrait of children with pertussis, meningococcal infectious, scarlet fever and estimation of their assigned pharmacotherapy.","journal":"Wiadomosci lekarskie (Warsaw, Poland : 1960)"},{"date":"2018 May","pmid":"29938679","title":"Antitussive activity of alcoxyphenyl carbamic acid analogues.","journal":"General physiology and biophysics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butamirate is a small molecule. It is also known by the synonyms butamirate, butamirate, butamirate, butamirato, and codimin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}