{"id":"butalamine","rwe":[{"pmid":"36453511","year":"2023","title":"Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole.","finding":"","journal":"Current organic synthesis","studyType":"Clinical Study"},{"pmid":"6767648","year":"1980","title":"[Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride].","finding":"","journal":"Fortschritte der Medizin","studyType":"Clinical Study"},{"pmid":"119287","year":"1979","title":"[Prolonged treatment of obliterantive arteritis with butalamine. Follow up study of 42 cases during more than 1 year of rheographic control].","finding":"","journal":"Revista clinica espanola","studyType":"Clinical Study"},{"pmid":"109382","year":"1979","title":"[Drug therapy of chronic arterial occlusive diseases of the lower extremities with butalamine-HCl].","finding":"","journal":"Fortschritte der Medizin","studyType":"Clinical Study"},{"pmid":"99596","year":"1978","title":"[Pharmacotherapy of peripheral arteriosclerosis].","finding":"","journal":"Kardiologiia","studyType":"Clinical Study"}],"tags":[{"label":"butalamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C04AX23","category":"atc"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["butalamine hydrochloride","butalamine","butalamine HCl"],"offLabel":[],"synonyms":["butalamine hydrochloride","butalamine","butalamine HCl"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"butalamine","explanation":"Imagine butalamine as a key that fits into a lock in the body. When it binds to its target, it can help to regulate various bodily functions, but the exact way it does this is still a mystery. More research is needed to understand how butalamine works and what effects it might have on the body.","oneSentence":"Butalamine is thought to work by interacting with a specific target in the body, although the exact nature of this interaction is not yet fully understood.","technicalDetail":"Butalamine is a small molecule that binds to a specific protein or receptor, potentially modulating its activity and influencing downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/440","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUTALAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:05:10.730993","biosimilars":[],"competitors":[{"drugName":"phenoxybenzamine","drugSlug":"phenoxybenzamine","fdaApproval":"1953-01-26","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"butalamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenoxybenzamine","brandName":"phenoxybenzamine","genericName":"phenoxybenzamine","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005243","UNII":"140T9JTG43","CHEBI":"CHEBI:135354","INN_ID":"2636","RXNORM":"180806","UMLSCUI":"C0644503","ChEMBL_ID":"CHEMBL1697825","KEGG_DRUG":"D07177","DRUGBANK_ID":"DB13681","PUBCHEM_CID":"30949","SECONDARY_CAS_RN":"56974-46-0","MESH_SUPPLEMENTAL_RECORD_UI":"C067591"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":13,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C04AX23","allCodes":["C04AX23"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023","pmid":"36453511","title":"Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole.","journal":"Current organic synthesis"},{"date":"1980 Feb 21","pmid":"6767648","title":"[Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride].","journal":"Fortschritte der Medizin"},{"date":"1979 Oct 31","pmid":"119287","title":"[Prolonged treatment of obliterantive arteritis with butalamine. Follow up study of 42 cases during more than 1 year of rheographic control].","journal":"Revista clinica espanola"},{"date":"1979 May 17","pmid":"109382","title":"[Drug therapy of chronic arterial occlusive diseases of the lower extremities with butalamine-HCl].","journal":"Fortschritte der Medizin"},{"date":"1978 Aug","pmid":"99596","title":"[Pharmacotherapy of peripheral arteriosclerosis].","journal":"Kardiologiia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"BUTALAMINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butalamine is a small molecule with the synonyms butalamina, butalamine, butalamine, LA 1221 free base, and LA-1221 free base.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}