{"id":"buspirone-and-grapefruit-juice","safety":{"commonSideEffects":[{"rate":"12","effect":"Dizziness"},{"rate":"10","effect":"Drowsiness"},{"rate":"6","effect":"Headache"},{"rate":"5","effect":"Nervousness"},{"rate":"3","effect":"Lightheadedness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Buspirone is an anxiolytic that binds to and partially activates serotonin 5-HT1A receptors in the brain, reducing anxiety symptoms. Grapefruit juice contains furanocoumarins that irreversibly inhibit intestinal and hepatic CYP3A4 enzyme, significantly reducing first-pass metabolism of buspirone and elevating its systemic exposure. This interaction is clinically relevant as it can increase buspirone levels and potentially enhance both therapeutic and adverse effects.","oneSentence":"Buspirone acts as a serotonin 5-HT1A receptor partial agonist, while grapefruit juice inhibits CYP3A4 metabolism, increasing buspirone bioavailability and plasma concentrations.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:00.721Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Generalized anxiety disorder (buspirone monotherapy)"},{"name":"Drug-drug interaction study / pharmacokinetic investigation (buspirone + grapefruit juice combination)"}]},"trialDetails":[{"nctId":"NCT02483598","phase":"PHASE4","title":"Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone","status":"TERMINATED","sponsor":"North Dakota State University","startDate":"2015-06","conditions":"Gastric Bypass","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Buspirone and Grapefruit Juice","genericName":"Buspirone and Grapefruit Juice","companyName":"North Dakota State University","companyId":"north-dakota-state-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Buspirone acts as a serotonin 5-HT1A receptor partial agonist, while grapefruit juice inhibits CYP3A4 metabolism, increasing buspirone bioavailability and plasma concentrations. Used for Generalized anxiety disorder (buspirone monotherapy), Drug-drug interaction study / pharmacokinetic investigation (buspirone + grapefruit juice combination).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}