{"id":"buproprionsr","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Insomnia"},{"rate":"15-25","effect":"Dry mouth"},{"rate":"15-20","effect":"Headache"},{"rate":"10-15","effect":"Nausea"},{"rate":"10-15","effect":"Agitation"},{"rate":"0.4","effect":"Seizures"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By inhibiting the reuptake of norepinephrine and dopamine, bupropion SR prolongs the presence of these neurotransmitters in the synaptic cleft, enhancing their signaling. This mechanism differs from selective serotonin reuptake inhibitors (SSRIs) and makes it particularly useful for depression with anhedonia or fatigue. The SR (sustained-release) formulation provides extended drug delivery over 12 hours.","oneSentence":"Bupropion SR is a norepinephrine-dopamine reuptake inhibitor that increases levels of norepinephrine and dopamine in the brain by blocking their reuptake at the presynaptic neuron.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:11.948Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Seasonal affective disorder"},{"name":"Smoking cessation (as Zyban/Wellbutrin)"}]},"trialDetails":[{"nctId":"NCT00021528","phase":"PHASE4","title":"Sequenced Treatment Alternatives to Relieve Depression (STAR*D)","status":"COMPLETED","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2001-07","conditions":"Depression","enrollment":4000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"BuproprionSR","genericName":"BuproprionSR","companyName":"National Institute of Mental Health (NIMH)","companyId":"national-institute-of-mental-health-nimh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupropion SR is a norepinephrine-dopamine reuptake inhibitor that increases levels of norepinephrine and dopamine in the brain by blocking their reuptake at the presynaptic neuron. Used for Major depressive disorder, Seasonal affective disorder, Smoking cessation (as Zyban/Wellbutrin).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}