{"id":"buprenorphine-buccal-film-belbuca","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Application site irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Buprenorphine acts as a partial agonist at the mu-opioid receptor, meaning it produces a submaximal response compared to full agonists while maintaining high receptor binding affinity. This partial agonist profile provides analgesic efficacy with a lower ceiling effect on respiratory depression compared to full opioid agonists. The buccal film formulation allows transmucosal absorption for rapid onset of pain relief in chronic pain management.","oneSentence":"Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to opioid receptors in the central nervous system to provide analgesia and reduce pain perception.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:41:18.249Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain in opioid-tolerant patients"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Belbuca"],"phase":"marketed","status":"active","brandName":"Buprenorphine Buccal Film [Belbuca]","genericName":"Buprenorphine Buccal Film [Belbuca]","companyName":"Carolinas Pain Institute","companyId":"carolinas-pain-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to opioid receptors in the central nervous system to provide analgesia and reduce pain perception. Used for Chronic pain in opioid-tolerant patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}