{"id":"bupranolol","rwe":[{"pmid":"41485077","year":"2026","title":"Comparing the Molecular Pharmacological Properties of Existing β-Blockers to Determine the Theoretically Most \"Ideal\" Anti-Cancer β-Blocker.","finding":"","journal":"Pharmacology research & perspectives","studyType":"Clinical Study"},{"pmid":"40996115","year":"2025","title":"Influence of autonomic nervous system on relaxant action of bisphenol A in porcine myometrium.","finding":"","journal":"Polish journal of veterinary sciences","studyType":"Clinical Study"},{"pmid":"33640886","year":"2021","title":"Myometrial Responses to Beta-Adrenoceptor Antagonists in Gynecological Malignancies.","finding":"","journal":"Gynecologic and obstetric investigation","studyType":"Clinical Study"},{"pmid":"31837330","year":"2020","title":"Pharmacological properties of β-adrenoceptors mediating rat superior mesenteric artery relaxation and the effects of chemical sympathetic denervation.","finding":"","journal":"Life sciences","studyType":"Clinical Study"},{"pmid":"31069746","year":"2019","title":"Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins.","finding":"","journal":"Methods in molecular biology (Clifton, N.J.)","studyType":"Clinical Study"}],"tags":[{"label":"bupranolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-2 adrenergic receptor","category":"target"},{"label":"ADRB2","category":"gene"},{"label":"ADRB1","category":"gene"},{"label":"ADRB3","category":"gene"},{"label":"C07AA19","category":"atc"},{"label":"Active","category":"status"},{"label":"Glaucoma","category":"indication"},{"label":"Hypertensive disorder","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bupranol","offLabel":[],"synonyms":["bupranolol","(+/-)-Bupranolol","bupranol","bupranolol hydrochloride","bupranolol HCl"],"timeline":[],"brandName":"Bupranol","ecosystem":[{"indication":"Glaucoma","otherDrugs":[{"name":"acetylcholine","slug":"acetylcholine","company":""},{"name":"echothiophate","slug":"echothiophate","company":"Wyeth Pharms Inc"},{"name":"omidenepag isopropyl","slug":"omidenepag-isopropyl","company":"Santen"}],"globalPrevalence":1952000},{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Beta-2 adrenergic receptor","targets":[{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"},{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRB3","source":"DrugCentral","target":"Beta-3 adrenergic receptor","protein":"Beta-3 adrenergic receptor"}],"modality":"Small Molecule","drugClass":"bupranolol","explanation":"Think of it like a key fitting into a lock. The beta-2 adrenergic receptor is like a lock on a door, and Bupranol is the key that blocks it from being opened. When this lock is blocked, the pressure in the eye and blood pressure are reduced, which can help to treat glaucoma and hypertensive disorders.","oneSentence":"Bupranol works by blocking the beta-2 adrenergic receptor, which helps to reduce the pressure in the eye and lower blood pressure.","technicalDetail":"Bupranol acts as a competitive antagonist at the beta-2 adrenergic receptor, inhibiting the action of endogenous catecholamines such as epinephrine and norepinephrine, which are involved in the regulation of intraocular pressure and blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/433","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUPRANOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:08:32.093590","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:53:12.746094+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"oxprenolol","drugSlug":"oxprenolol","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"pindolol","drugSlug":"pindolol","fdaApproval":"1982-09-03","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"propranolol","drugSlug":"propranolol","fdaApproval":"1967-11-13","patentExpiry":"Oct 16, 2028","patentStatus":"Patent 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