{"id":"bupivacaine-liposomes-bl","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Systemic toxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. By encapsulating bupivacaine in liposomal carriers, the formulation extends the drug's duration of action, allowing for sustained anesthetic effect over an extended period compared to conventional bupivacaine solutions.","oneSentence":"Bupivacaine liposomes is a long-acting local anesthetic formulation that delivers bupivacaine encapsulated in lipid vesicles to provide prolonged nerve blockade and pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:02.421Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia and analgesia for surgical procedures"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT06737341","phase":"PHASE4","title":"Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2025-10-08","conditions":"Bupivacaine, Ultrasound-Guided, Analgesia, Postoperative","enrollment":60},{"nctId":"NCT06972680","phase":"","title":"Determination of the Optimal Volume of 0.5% Bupivacaine Liposome in Single-Injection Interscalene Brachial Plexus Block: A Bayesian Phase I/II Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Affiliated Hospital of Jiaxing University","startDate":"2025-05-01","conditions":"Shoulder Arthroscopy","enrollment":60},{"nctId":"NCT04134442","phase":"PHASE4","title":"Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome","status":"WITHDRAWN","sponsor":"University of Massachusetts, Worcester","startDate":"2019-12-09","conditions":"Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Bupivacaine Liposomes(BL)","genericName":"Bupivacaine Liposomes(BL)","companyName":"Huazhong University of Science and Technology","companyId":"huazhong-university-of-science-and-technology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine liposomes is a long-acting local anesthetic formulation that delivers bupivacaine encapsulated in lipid vesicles to provide prolonged nerve blockade and pain relief. Used for Local anesthesia and analgesia for surgical procedures, Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}