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The intraperitoneally route allows direct contact with peritoneal surfaces and visceral innervation.","oneSentence":"Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:09.704Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia and analgesia for intra-abdominal procedures via intraperitoneal administration"}]},"trialDetails":[{"nctId":"NCT07429448","phase":"PHASE1","title":"Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy","status":"RECRUITING","sponsor":"Sardar Umer Rehman","startDate":"2025-12-16","conditions":"Appendectomy","enrollment":60},{"nctId":"NCT07388251","phase":"NA","title":"Effect of Intraperitoneal Dexmedetomidine Added to Bupivacaine 0.25% Versus 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molecule","firstApprovalDate":"","aiSummary":"Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia and analgesia for intra-abdominal procedures via intraperitoneal administration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}