{"id":"bupivacaine-hcl-collagen-matrix-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Local site reactions"},{"rate":null,"effect":"Infection at implant site"},{"rate":null,"effect":"Delayed wound healing"},{"rate":null,"effect":"Systemic bupivacaine toxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug combines bupivacaine, a long-acting local anesthetic, with a biodegradable collagen matrix that serves as a depot delivery system. The collagen matrix gradually releases bupivacaine over time, providing prolonged local anesthetic effect at the implantation site to reduce postoperative pain. This approach aims to minimize systemic exposure while maintaining localized anesthetic coverage during the critical postoperative period.","oneSentence":"Bupivacaine HCl is released from a collagen matrix implant to provide local anesthesia at the surgical site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:55:20.049Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management following surgical procedures"}]},"trialDetails":[{"nctId":"NCT04785625","phase":"PHASE3","title":"Efficacy and Safety Study of Postsurgical Analgesia With INL-001 in Abdominoplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2021-04-29","conditions":"Pain, Postoperative, Abdominoplasty","enrollment":366},{"nctId":"NCT03262688","phase":"PHASE3","title":"Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair","status":"UNKNOWN","sponsor":"Innocoll","startDate":"2017-06-16","conditions":"Inguinal Hernia, Postoperative Pain","enrollment":159},{"nctId":"NCT03234374","phase":"PHASE1","title":"Pharmacokinetics, Relative Bioavailability and Safety of INL-001 Compared to Marcaine After Open Hernioplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2017-06-02","conditions":"Hernioplasty","enrollment":52},{"nctId":"NCT01220024","phase":"PHASE2","title":"Safety and Efficacy of CollaRx® Bupivacaine Implant in Men After Open Laparotomy Herniorrhaphy","status":"COMPLETED","sponsor":"Innocoll","startDate":"2010-12-02","conditions":"Herniorrhaphy, Postoperative Pain, Inguinal Hernia","enrollment":50},{"nctId":"NCT02525133","phase":"PHASE3","title":"Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2015-09-05","conditions":"Pain, Postoperative","enrollment":319}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xaracoll"],"phase":"phase_3","status":"active","brandName":"Bupivacaine HCl collagen-matrix implant","genericName":"Bupivacaine HCl collagen-matrix implant","companyName":"Innocoll","companyId":"innocoll","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine HCl is released from a collagen matrix implant to provide local anesthesia at the surgical site. Used for Postoperative pain management following surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}