{"id":"bupivacaine-fentanyl","brandName":"Bupivacaine-fentanyl","genericName":"Bupivacaine-fentanyl","companyId":"abdelrady-s-ibrahim-md","companyName":"Abdelrady S Ibrahim, MD","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Epidural Catheter insertion","Spinal Anesthesia","Marcaine","Sensorcaine","Astra Zeneca"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Bupivacaine-fentanyl is a combination anesthetic and analgesic used primarily for regional anesthesia and pain management. Despite no FDA label, it is widely studied in various surgical and labor settings, showing promise in reducing postoperative pain and improving patient outcomes.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting amide local anesthetic that blocks sodium channels in nerve fibers, preventing action potential propagation and numbing sensation in a localized area. Fentanyl is a potent synthetic opioid that binds to mu-opioid receptors in the central and peripheral nervous system to provide additional analgesia. Together, they provide synergistic pain relief for regional anesthesia and analgesia.","oneSentence":"Bupivacaine-fentanyl is a combination of a local anesthetic and an opioid analgesic that blocks nerve conduction and provides pain relief through multiple mechanisms.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"trials":[],"indications":{"approved":[{"name":"Regional anesthesia and analgesia for surgical procedures"},{"name":"Postoperative pain management"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":7,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}