{"id":"buphenine","rwe":[{"pmid":"41679162","year":"2026","title":"A new HPTLC-image analysis approach for assessing interactions and antioxidant profiles of adrenergic drugs.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"},{"pmid":"22364032","year":"2011","title":"[Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age].","finding":"","journal":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","studyType":"Clinical Study"},{"pmid":"9548292","year":"1998","title":"Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis (II).","finding":"","journal":"Electrophoresis","studyType":"Clinical Study"},{"pmid":"1388340","year":"1992","title":"[Generalized exanthematous pustulosis caused by buphenine: report of a case].","finding":"","journal":"Annales de dermatologie et de venereologie","studyType":"Clinical Study"},{"pmid":"1971738","year":"1990","title":"Decreased numbers of lymphocyte beta 2-adrenoceptors in pregnant women receiving beta 2-adrenergic agonist therapy.","finding":"","journal":"Acta obstetricia et gynecologica Scandinavica","studyType":"Clinical Study"}],"tags":[{"label":"buphenine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adrenergic receptor alpha-1","category":"target"},{"label":"ADRA1A","category":"gene"},{"label":"ADRA1B","category":"gene"},{"label":"ADRA1D","category":"gene"},{"label":"C04AA02","category":"atc"},{"label":"Active","category":"status"},{"label":"Disorder of blood vessel","category":"indication"},{"label":"Inner Ear Disturbance","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Tocolytic Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"unknown","safety":{"contraindications":["Decompensated cardiac failure","Heart disease","Myocardial infarction","Myocardial infarction in recovery phase","Paroxysmal tachycardia","Progressive Angina Pectoris","Tachyarrhythmia","Thyrotoxicosis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"buphenin","offLabel":[],"synonyms":["nylidrin hydrochloride","nylidrin","buphenin","buphenine","nilidrine","nylidrin HCl"],"timeline":[],"brandName":"Buphenin","ecosystem":[{"indication":"Disorder of blood vessel","otherDrugs":[{"name":"isoxsuprine","slug":"isoxsuprine","company":""},{"name":"tolazoline","slug":"tolazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Inner Ear Disturbance","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Adrenergic receptor alpha-1","targets":[{"gene":"ADRA1A","source":"DrugCentral","target":"Adrenergic receptor alpha-1","protein":"Alpha-1A adrenergic receptor"},{"gene":"ADRA1B","source":"DrugCentral","target":"Adrenergic receptor alpha-1","protein":"Alpha-1B adrenergic receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Adrenergic receptor alpha-1","protein":"Alpha-1D adrenergic receptor"}],"modality":"Small Molecule","drugClass":"buphenine","explanation":"Imagine your blood vessels are like roads in your body. When buphenine stimulates the alpha-1 receptors, it's like putting up a traffic light that says 'go' to the blood flow, helping it move more efficiently through the roads. This can help improve blood flow to areas that need it, like the inner ear.","oneSentence":"Buphenine works by stimulating the alpha-1 adrenergic receptors, which helps to constrict blood vessels and improve blood flow.","technicalDetail":"Buphenine acts as an agonist at the alpha-1 adrenergic receptor, triggering a cascade of downstream effects that ultimately lead to vasoconstriction and increased blood flow."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Buphenine","title":"Buphenine","extract":"Buphenine, also known as nylidrin and sold under the brand name Arlidin, is a β2 adrenoreceptor agonist that acts as a vasodilator."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1976","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=buphenine","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Buphenine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:05:22.446769","biosimilars":[],"competitors":[{"drugName":"isoxsuprine","drugSlug":"isoxsuprine","fdaApproval":"","relationship":"same-class"}],"genericName":"buphenine","indications":{"approved":[{"name":"Disorder of blood vessel","source":"DrugCentral","snomedId":27550009,"regulator":"FDA"},{"name":"Inner Ear Disturbance","source":"DrugCentral","snomedId":"","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isoxsuprine","brandName":"isoxsuprine","genericName":"isoxsuprine","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000179434","NDDF":"000699","UNII":"EC69E3PW7E","VUID":"4017871","CHEBI":"CHEBI:31925","VANDF":"4017871","INN_ID":"461","RXNORM":"7595","UMLSCUI":"C0028735","ChEMBL_ID":"CHEMBL114655","KEGG_DRUG":"D01543","DRUGBANK_ID":"DB06152","PUBCHEM_CID":"4567","SNOMEDCT_US":"111140007","SECONDARY_CAS_RN":"849-55-8","MESH_DESCRIPTOR_UI":"D009756"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C04AA02","allCodes":["C04AA02","G02CA02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Apr 12","pmid":"41679162","title":"A new HPTLC-image analysis approach for assessing interactions and antioxidant profiles of adrenergic drugs.","journal":"Journal of chromatography. A"},{"date":"2011 Jul-Aug","pmid":"22364032","title":"[Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age].","journal":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion"},{"date":"1998 Feb","pmid":"9548292","title":"Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis (II).","journal":"Electrophoresis"},{"date":"1992","pmid":"1388340","title":"[Generalized exanthematous pustulosis caused by buphenine: report of a case].","journal":"Annales de dermatologie et de venereologie"},{"date":"1990","pmid":"1971738","title":"Decreased numbers of lymphocyte beta 2-adrenoceptors in pregnant women receiving beta 2-adrenergic agonist therapy.","journal":"Acta obstetricia et gynecologica Scandinavica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Buphenine is a small molecule drug that targets the adrenergic receptor alpha-1. It is used to treat disorders of blood vessels and inner ear disturbances. The commercial status of buphenine is unclear, as it is not listed as a patented or off-patent drug. Buphenine's safety considerations are also unknown due to a lack of FDA approval. Further research is needed to fully understand its pharmacological properties.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}