{"id":"bunitrolol","rwe":[],"tags":[{"label":"bunitrolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":["NCT00558155"],"aliases":[],"patents":[],"pricing":[],"allNames":"stresson","offLabel":[],"synonyms":["bunitrolol hydrochloride","stresson","bunitrolol","(+/-)-Bunitrolol","dl-Bunitrolol","bunitrolol HCl"],"timeline":[],"brandName":"Stresson","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bunitrolol","explanation":"Imagine your body's 'fight or flight' response, which is triggered by the hormone epinephrine. Bunitrolol helps to slow down this response by blocking the action of epinephrine on the heart and blood vessels, which can help to reduce blood pressure and heart rate.","oneSentence":"Bunitrolol is a beta-adrenergic receptor blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline.","technicalDetail":"Bunitrolol is a selective beta-1 adrenergic receptor antagonist that competes with epinephrine for binding to beta-1 receptors in the heart, resulting in decreased heart rate and contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/430","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUNITROLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:08:24.296484","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"bunitrolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00558155","phase":"Phase 4","title":"Title: The Impact of Immunostimulating Nutrition on Infectious Complications After Upper Gastrointestinal Surgery - A Prospective, Randomized, Clinical Trial.","status":"COMPLETED","sponsor":"Jagiellonian University","isPivotal":false,"enrollment":214,"indication":"Gastric Cancer, Pancreatic Cancer","completionDate":"2005-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"F2613LO055","CHEBI":"CHEBI:31321","INN_ID":"3266","UMLSCUI":"C0006387","ChEMBL_ID":"CHEMBL418134","KEGG_DRUG":"D01444","PUBCHEM_CID":"2473","SECONDARY_CAS_RN":"29876-08-2","MESH_SUPPLEMENTAL_RECORD_UI":"C084811"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":101,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Stresson is a small molecule intervention used in clinical trials for Gastric Cancer and Pancreatic Cancer. It was studied in a prospective, randomized trial (NCT00558155) as part of immunostimulating nutrition to reduce infectious complications after upper gastrointestinal surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}