{"id":"bunaftine","rwe":[{"pmid":"9422155","year":"1994","title":"Predictors of successful at-home chemical cardioversion in new-onset atrial fibrillation.","finding":"","journal":"European journal of emergency medicine : official journal of the European Society for Emergency Medicine","studyType":"Clinical Study"},{"pmid":"3093338","year":"1986","title":"[Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations].","finding":"","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","studyType":"Clinical Study"},{"pmid":"6201280","year":"1984","title":"Effects of bunaftine on morphology, microfilament integrity, and mitotic activity in cultured human fibroblasts and HeLa cells.","finding":"","journal":"Cell and tissue research","studyType":"Clinical Study"},{"pmid":"6876382","year":"1983","title":"Intropic effects of several antiarrhythmic drugs.","finding":"","journal":"Japanese heart journal","studyType":"Clinical Study"},{"pmid":"7112484","year":"1982","title":"[Pharmacokinetics of a new antiarrhythmic drug, bunaftine, after oral administration (author's transl)].","finding":"","journal":"Therapie","studyType":"Clinical Study"}],"tags":[{"label":"bunaftine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01BD03","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bunaftide","offLabel":[],"synonyms":["bunaftine","bunaftide","bunaphtide"],"timeline":[],"brandName":"Bunaftide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bunaftine","explanation":"Imagine your body's cells are like locks, and the key to unlocking a specific problem is a molecule that fits perfectly into that lock. Bunaftine is designed to be that key, but the exact lock it fits into is not well understood. By binding to this target, bunaftine aims to modulate the body's response to a particular condition.","oneSentence":"Bunaftine works by interacting with a specific target to produce its therapeutic effect.","technicalDetail":"Bunaftine's mechanism of action involves binding to a specific protein or receptor, which triggers a cascade of downstream effects that ultimately lead to its therapeutic outcome."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/428","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUNAFTINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:04:04.630267","biosimilars":[],"competitors":[{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"bretylium","drugSlug":"bretylium","fdaApproval":"1986-03-06","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dofetilide","drugSlug":"dofetilide","fdaApproval":"1999-10-01","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibutilide","drugSlug":"ibutilide","fdaApproval":"1995-12-28","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dronedarone","drugSlug":"dronedarone","fdaApproval":"2009-07-01","patentExpiry":"Jun 30, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"bunaftine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-class"},{"drugId":"bretylium","brandName":"bretylium","genericName":"bretylium","approvalYear":"1986","relationship":"same-class"},{"drugId":"dofetilide","brandName":"dofetilide","genericName":"dofetilide","approvalYear":"1999","relationship":"same-class"},{"drugId":"ibutilide","brandName":"ibutilide","genericName":"ibutilide","approvalYear":"1995","relationship":"same-class"},{"drugId":"dronedarone","brandName":"dronedarone","genericName":"dronedarone","approvalYear":"2009","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"GH09PRQ3FU","CHEBI":"CHEBI:135392","INN_ID":"3387","UMLSCUI":"C0006378","ChEMBL_ID":"CHEMBL2104200","KEGG_DRUG":"D07428","DRUGBANK_ID":"DB13652","PUBCHEM_CID":"36131","MESH_DESCRIPTOR_UI":"D002035"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":26,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C01BD03","allCodes":["C01BD03"]},"biosimilarFilings":[],"recentPublications":[{"date":"1994 Sep","pmid":"9422155","title":"Predictors of successful at-home chemical cardioversion in new-onset atrial fibrillation.","journal":"European journal of emergency medicine : official journal of the European Society for Emergency Medicine"},{"date":"1986 Jul","pmid":"3093338","title":"[Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations].","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica"},{"date":"1984","pmid":"6201280","title":"Effects of bunaftine on morphology, microfilament integrity, and mitotic activity in cultured human fibroblasts and HeLa cells.","journal":"Cell and tissue research"},{"date":"1983 May","pmid":"6876382","title":"Intropic effects of several antiarrhythmic drugs.","journal":"Japanese heart journal"},{"date":"1982 Mar-Apr","pmid":"7112484","title":"[Pharmacokinetics of a new antiarrhythmic drug, bunaftine, after oral administration (author's transl)].","journal":"Therapie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bunaftine is a small molecule drug in the bunaftine class, developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. The commercial status of bunaftine is unclear, with unknown patent status and generic manufacturers. Further information on its approved indications, half-life, and bioavailability is also unavailable. As a result, key safety considerations and clinical use cannot be accurately assessed.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}