{"id":"bufylline","rwe":[{"pmid":"793781","year":"1976","title":"Double-blind trial of a long-acting bronchodilator preparation (\"Nethaprin Dospan\") in bronchospastic disease.","finding":"","journal":"Current medical research and opinion","studyType":"Clinical Study"}],"tags":[{"label":"bufylline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adenosine receptor A1","category":"target"},{"label":"ADORA1","category":"gene"},{"label":"ADORA2A","category":"gene"},{"label":"ADORA3","category":"gene"},{"label":"R03DA10","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ambuphylline","offLabel":[],"synonyms":["bufylline","ambuphylline","butaphyllamine","theophylline aminoisobutanol"],"timeline":[],"brandName":"Ambuphylline","ecosystem":[],"mechanism":{"target":"Adenosine receptor A3, Alkaline phosphatase, tissue-nonspecific isozyme, Adenosine receptor A1","targets":[{"gene":"ADORA1","source":"DrugCentral","target":"Adenosine receptor A1","protein":"Adenosine receptor A1"},{"gene":"ADORA2A","source":"DrugCentral","target":"Adenosine receptor A2a","protein":"Adenosine receptor A2a"},{"gene":"ADORA3","source":"DrugCentral","target":"Adenosine receptor A3","protein":"Adenosine receptor A3"},{"gene":"ADORA2B","source":"DrugCentral","target":"Adenosine receptor A2b","protein":"Adenosine receptor A2b"},{"gene":"PDE4A","source":"DrugCentral","target":"Phosphodiesterase 4","protein":"cAMP-specific 3',5'-cyclic phosphodiesterase 4A"},{"gene":"PDE4B","source":"DrugCentral","target":"Phosphodiesterase 4","protein":"cAMP-specific 3',5'-cyclic phosphodiesterase 4B"},{"gene":"PDE4C","source":"DrugCentral","target":"Phosphodiesterase 4","protein":"cAMP-specific 3',5'-cyclic phosphodiesterase 4C"},{"gene":"PDE4D","source":"DrugCentral","target":"Phosphodiesterase 4","protein":"cAMP-specific 3',5'-cyclic phosphodiesterase 4D"},{"gene":"PIK3CD","source":"DrugCentral","target":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform","protein":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform"},{"gene":"ALPL","source":"DrugCentral","target":"Alkaline phosphatase, tissue-nonspecific isozyme","protein":"Alkaline phosphatase, tissue-nonspecific isozyme"}],"modality":"Small Molecule","drugClass":"bufylline","explanation":"Think of adenosine like a brake pedal in your car. When adenosine binds to its receptor, it slows down the heart rate and lowers blood pressure. Ambuphylline blocks this brake pedal, allowing the heart to beat faster and blood pressure to rise.","oneSentence":"Ambuphylline works by blocking the adenosine receptor A1, which helps to increase heart rate and blood pressure.","technicalDetail":"Ambuphylline acts as a competitive antagonist at the adenosine receptor A1, inhibiting the Gi/o protein-mediated signaling pathway and increasing the activity of the sympathetic nervous system."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ambuphylline","title":"Ambuphylline","extract":"Ambuphylline is a combination of theophylline and aminoisobutanol used as a bronchodilator. It also acts and may be used as a diuretic."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4426","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=bufylline","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ambuphylline","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:08:10.164404","biosimilars":[],"competitors":[{"drugName":"diprophylline","drugSlug":"diprophylline","fdaApproval":"1951-03-07","relationship":"same-class"},{"drugName":"choline theophyllinate","drugSlug":"choline-theophyllinate","fdaApproval":"1981-11-05","relationship":"same-class"},{"drugName":"theophylline","drugSlug":"theophylline","fdaApproval":"1940-04-19","genericCount":53,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"bufylline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diprophylline","brandName":"diprophylline","genericName":"diprophylline","approvalYear":"1951","relationship":"same-class"},{"drugId":"choline-theophyllinate","brandName":"choline theophyllinate","genericName":"choline theophyllinate","approvalYear":"1981","relationship":"same-class"},{"drugId":"theophylline","brandName":"theophylline","genericName":"theophylline","approvalYear":"1940","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006001","UNII":"VOU5V0B772","UMLSCUI":"C3652921","ChEMBL_ID":"CHEMBL2104089","KEGG_DRUG":"D02884","DRUGBANK_ID":"DB13812","PUBCHEM_CID":"21850","SNOMEDCT_US":"7302008","MESH_SUPPLEMENTAL_RECORD_UI":"C006485"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"R03DA10","allCodes":["R03DA10"]},"biosimilarFilings":[],"recentPublications":[{"date":"1976","pmid":"793781","title":"Double-blind trial of a long-acting bronchodilator preparation (\"Nethaprin Dospan\") in bronchospastic disease.","journal":"Current medical research and opinion"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Ambuphylline, also known as bufylline, is a small molecule drug that targets the adenosine receptor A1. It is a bufylline, a class of drugs that work by modulating adenosine receptors. However, its commercial status and approved indications are unknown. As a result, its half-life, bioavailability, and generic manufacturers are also unclear. Further research is needed to determine its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}