{"id":"bufogenin","rwe":[{"pmid":"40810388","year":"2025","title":"Morphology and Chemical Composition of the Nuchal Glands of Indonesian Snakes With a Description of a Novel Type of Glands.","finding":"","journal":"Journal of morphology","studyType":"Clinical Study"},{"pmid":"39051843","year":"2024","title":"Bufadienolide-Fatty Acid Conjugates from the Fertilized Eggs of Toad Bufo gargarizans: Isolation, Characterization, Toxicity, and Antiproliferative Evaluation.","finding":"","journal":"Journal of agricultural and food chemistry","studyType":"Clinical Study"},{"pmid":"38198886","year":"2024","title":"Integrated post-acquisition data processing strategy for rapid steroid sulfate characterization in Toad gall-bladder.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"36592847","year":"2023","title":"Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo-aminopeptidases; relationship with effects on human melanoma MeWo cells.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"33104363","year":"2020","title":"Unified Total Synthesis of Five Bufadienolides.","finding":"","journal":"Organic letters","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"respigon","offLabel":[],"synonyms":["resibufogenin","bufogenin","recibufogenin","respigon"],"timeline":[],"brandName":"Respigon","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your cells have locks on them, and Respigon has a key that fits into those locks. When it binds to the lock, it triggers a series of events that ultimately lead to a desired outcome, such as reducing inflammation or blocking a disease-causing process. This is a simplified explanation of how small molecules like Respigon can affect cellular behavior.","oneSentence":"Respigon works by interacting with a specific cellular target to produce a therapeutic effect.","technicalDetail":"Respigon (BUFOGENIN) is a small molecule that binds to a specific protein target, modulating its activity and leading to a downstream effect on cellular signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3523","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUFOGENIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:08:06.040169","biosimilars":[],"competitors":[],"genericName":"bufogenin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3K654P2M4J","CHEBI":"CHEBI:31319","INN_ID":"1960","UMLSCUI":"C0054208","ChEMBL_ID":"CHEMBL250172","KEGG_DRUG":"D01378","PDB_CHEM_ID":" 6JI","PUBCHEM_CID":"6917974","SNOMEDCT_US":"55508006","MESH_SUPPLEMENTAL_RECORD_UI":"C005734"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Aug","pmid":"40810388","title":"Morphology and Chemical Composition of the Nuchal Glands of Indonesian Snakes With a Description of a Novel Type of Glands.","journal":"Journal of morphology"},{"date":"2024 Aug 7","pmid":"39051843","title":"Bufadienolide-Fatty Acid Conjugates from the Fertilized Eggs of Toad Bufo gargarizans: Isolation, Characterization, Toxicity, and Antiproliferative Evaluation.","journal":"Journal of agricultural and food chemistry"},{"date":"2024 Mar 15","pmid":"38198886","title":"Integrated post-acquisition data processing strategy for rapid steroid sulfate characterization in Toad gall-bladder.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2023 Feb 28","pmid":"36592847","title":"Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo-aminopeptidases; relationship with effects on human melanoma MeWo cells.","journal":"International journal of biological macromolecules"},{"date":"2020 Nov 6","pmid":"33104363","title":"Unified Total Synthesis of Five Bufadienolides.","journal":"Organic letters"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Respigon (BUFOGENIN) is a small molecule modality with unknown target and drug class. Its commercial status is unclear, and it is not FDA approved for any indications. The drug's pharmacokinetic properties, including half-life and bioavailability, are also unknown. Further research is needed to understand its mechanism of action and potential therapeutic applications. As a result, key safety considerations and generic manufacturers are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}