{"id":"buffered-pantoprazole","safety":{"commonSideEffects":[{"rate":"12","effect":"Headache"},{"rate":"9","effect":"Diarrhea"},{"rate":"7","effect":"Nausea"},{"rate":"6","effect":"Abdominal pain"},{"rate":"4","effect":"Flatulence"},{"rate":"3","effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pantoprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inactivates the H+/K+-ATPase enzyme on the secretory surface of gastric parietal cells, preventing the final step of gastric acid production. The buffered formulation contains sodium bicarbonate to neutralize gastric acid in the stomach, allowing the pantoprazole to be absorbed in the small intestine where it is activated. This combination provides rapid symptom relief while the PPI provides sustained acid suppression.","oneSentence":"Buffered pantoprazole inhibits gastric acid secretion by blocking the proton pump (H+/K+-ATPase) in parietal cells of the stomach.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:50.943Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT01214408","phase":"PHASE4","title":"Effect of Digene Total (Buffered Pantoprazole) on 24 Hour Gastric Potential Hydrogen (pH) in Patients From Acid Peptic Disorder After Single and Repeated Dosing.","status":"COMPLETED","sponsor":"Abbott","startDate":"2011-03","conditions":"Acid Peptic Disorder","enrollment":47}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":50,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ABT-897, Buffered Pantoprazole, Digene Total"],"phase":"marketed","status":"active","brandName":"Buffered pantoprazole","genericName":"Buffered pantoprazole","companyName":"Abbott","companyId":"abbott","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Buffered pantoprazole inhibits gastric acid secretion by blocking the proton pump (H+/K+-ATPase) in parietal cells of the stomach. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}