{"id":"bufetolol","rwe":[{"pmid":"2860906","year":"1985","title":"Different effects of various beta-adrenoceptor antagonists on adenylate cyclase, guanylate cyclase and calmodulin-dependent phosphodiesterase in heart.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"6315283","year":"1983","title":"Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs.","finding":"","journal":"Clinical and experimental pharmacology & physiology","studyType":"Clinical Study"},{"pmid":"6138715","year":"1983","title":"Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"6132016","year":"1983","title":"Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension.","finding":"","journal":"Japanese circulation journal","studyType":"Clinical Study"},{"pmid":"6125176","year":"1982","title":"Effects of beta-adrenoceptor antagonists on central haemodynamics in essential hypertension.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"bufetolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["bufetolol","bufetolol hydrochloride","bufetolol HCl"],"offLabel":[],"synonyms":["bufetolol","bufetolol hydrochloride","bufetolol HCl"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bufetolol","explanation":"Imagine your body's cells have locks on them, and BUFETOLOL is a key that fits into one of those locks. When it binds, it can either turn the lock on or off, but we don't know which lock it's meant to interact with or how it affects the body's functions.","oneSentence":"BUFETOLOL is a small molecule that works by interacting with a specific target in the body, but its exact mechanism is unknown.","technicalDetail":"BUFETOLOL is a small molecule that likely interacts with a specific protein or receptor in the body, but its precise binding site and downstream effects are unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3046","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUFETOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:04:40.774384","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:02:30.629770+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"bufetolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"WS1467RT9Z","CHEBI":"CHEBI:31316","INN_ID":"3412","UMLSCUI":"C0107454","ChEMBL_ID":"CHEMBL347830","KEGG_DRUG":"D01504","PUBCHEM_CID":"2465","SECONDARY_CAS_RN":"35108-88-4","MESH_SUPPLEMENTAL_RECORD_UI":"C100228"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":12,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1985 May 15","pmid":"2860906","title":"Different effects of various beta-adrenoceptor antagonists on adenylate cyclase, guanylate cyclase and calmodulin-dependent phosphodiesterase in heart.","journal":"Biochemical pharmacology"},{"date":"1983 Sep-Oct","pmid":"6315283","title":"Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs.","journal":"Clinical and experimental pharmacology & physiology"},{"date":"1983 Sep","pmid":"6138715","title":"Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"1983 Mar","pmid":"6132016","title":"Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension.","journal":"Japanese circulation journal"},{"date":"1982","pmid":"6125176","title":"Effects of beta-adrenoceptor antagonists on central haemodynamics in essential hypertension.","journal":"British journal of clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"BUFETOLOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BUFETOLOL is a small molecule with the synonyms BUFETOLOL, Y 6124 FREE BASE, and Y-6124 FREE BASE.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:02:30.629770+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}