{"id":"budralazine","rwe":[],"tags":[{"label":"budralazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"buterazine","offLabel":[],"synonyms":["budralazine","buterazine","budralazine monohydrochloride","budralazine hydrochloride","budralazine HCl"],"timeline":[],"brandName":"Buterazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"budralazine","explanation":"Think of it like a traffic jam in your body. When you have diabetes, your body produces too much sugar, which can cause damage to your organs and nerves. Buterazine helps to reduce this traffic jam by blocking the enzyme that allows sugar to build up in the first place.","oneSentence":"Buterazine works by inhibiting the enzyme aldose reductase, which plays a key role in the development of diabetic complications.","technicalDetail":"Budralazine acts as a competitive inhibitor of aldose reductase, thereby reducing the accumulation of sorbitol in diabetic tissues and mitigating the associated complications."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/421","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUDRALAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:03:43.913287","biosimilars":[],"competitors":[],"genericName":"budralazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"S0177QHV2B","CHEBI":"CHEBI:134979","INN_ID":"3750","UMLSCUI":"C0054203","ChEMBL_ID":"CHEMBL2107516","KEGG_DRUG":"D01997","PUBCHEM_CID":"6419536","MESH_SUPPLEMENTAL_RECORD_UI":"C006153"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":25,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Buterazine is a small molecule. It is also known by the synonyms BUDRALAZINA, BUDRALAZINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}