{"id":"budesonide-200-microgram","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Dyspepsia"},{"rate":"5-10%","effect":"Cough"},{"rate":"1-5%","effect":"Thrush"},{"rate":"1-5%","effect":"Hypersensitivity reactions"},{"rate":"1-5%","effect":"Bone fractures"},{"rate":"1-5%","effect":"Osteoporosis"},{"rate":"1-5%","effect":"Growth suppression"},{"rate":"1-5%","effect":"Adrenal insufficiency"}]},"_chembl":{"chemblId":"CHEMBL1370","moleculeType":"Small molecule","molecularWeight":"430.54"},"_fixedAt":"2026-03-30T16:45:37.904560","_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Budesonide exerts its effects by binding to the glucocorticoid receptor, which then translocates to the nucleus and regulates the expression of various genes involved in inflammation. This leads to a decrease in the production of pro-inflammatory cytokines and other mediators, resulting in anti-inflammatory effects.","oneSentence":"Budesonide is a corticosteroid that works by inhibiting the release of pro-inflammatory mediators from mast cells and other cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:58:53.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Maintenance treatment of asthma"},{"name":"Ultrasonographically active inflammatory lesions of Crohn's disease"}]},"_fixedFields":["pubmed(8)"],"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"recentPublications":[{"date":"2001 May","pmid":"11802977","title":"[A study on pathological changes and the potential role of growth factors in the airway wall remodeling of COPD rat models].","journal":"Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases"},{"date":"2001 Apr","pmid":"11385814","title":"Stability and performance characteristics of a budesonide powder for inhalation with a novel dry powder inhaler device.","journal":"Current opinion in pulmonary medicine"},{"date":"2000 Oct","pmid":"11029334","title":"Antiasthmatic effects of mediator blockade versus topical corticosteroids in allergic rhinitis and asthma.","journal":"American journal of respiratory and critical care medicine"},{"date":"1999 Jul","pmid":"10400838","title":"Administration of budesonide once daily by means of turbuhaler to subjects with stable asthma.","journal":"The Journal of allergy and clinical immunology"},{"date":"1998 Dec","pmid":"9847429","title":"Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis.","journal":"The Journal of allergy and clinical immunology"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pulmicort"],"phase":"phase_2","status":"active","brandName":"Budesonide 200 microgram","genericName":"Budesonide 200 microgram","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Budesonide is a corticosteroid that works by inhibiting the release of pro-inflammatory mediators from mast cells and other cells. Used for Maintenance treatment of asthma, Ultrasonographically active inflammatory lesions of Crohn's disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}