{"id":"bucladesine","rwe":[{"pmid":"41763362","year":"2026","title":"Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment.","finding":"","journal":"Virus research","studyType":"Clinical Study"},{"pmid":"39111545","year":"2024","title":"Screening of novel disease genes of sepsis-induced myocardial Disfunction by RNA sequencing and bioinformatics analysis.","finding":"","journal":"Genomics","studyType":"Clinical Study"},{"pmid":"38734364","year":"2024","title":"End-ischemic pharmacological cocktail treatment to mitigate rewarming/reperfusion injury.","finding":"","journal":"Cryobiology","studyType":"Clinical Study"},{"pmid":"38556323","year":"2024","title":"Effects of glucagon-like peptide-1 receptor agonists on spermatogenesis-related gene expression in mouse testis and testis-derived cell lines.","finding":"","journal":"The Journal of veterinary medical science","studyType":"Clinical Study"},{"pmid":"38312248","year":"2024","title":"Successful treatment of ulceration in hidradenitis suppurativa with topical bucladesine: A case report.","finding":"","journal":"Skin health and disease","studyType":"Clinical Study"}],"tags":[{"label":"bucladesine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01CE04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dbcamp","offLabel":[],"synonyms":["bucladesine","Dibutyryl cAMP","dbcAMP","Cyclic AMP dibutyrate","bucladesine sodium","bucladesine sodium salt"],"timeline":[],"brandName":"Dbcamp","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bucladesine","explanation":"Think of cAMP like a messenger that helps to relax muscles and improve blood flow. When cAMP levels are low, muscles can become stiff and blood flow can be restricted. Dbcamp helps to increase cAMP levels, which can help to improve blood flow and reduce muscle stiffness.","oneSentence":"Dbcamp works by increasing levels of cyclic AMP (cAMP) in the body, which helps to relax smooth muscle and improve blood flow.","technicalDetail":"Dbcamp acts as a phosphodiesterase inhibitor, specifically inhibiting PDE3 and PDE4 enzymes, which break down cAMP. By inhibiting these enzymes, Dbcamp increases the levels of cAMP in the body, leading to relaxation of smooth muscle and improved blood flow."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/415","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BUCLADESINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:03:32.769186","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:12.470478+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"amrinone","drugSlug":"amrinone","fdaApproval":"1984-07-31","relationship":"same-class"},{"drugName":"milrinone","drugSlug":"milrinone","fdaApproval":"1987-12-31","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"bucladesine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amrinone","brandName":"amrinone","genericName":"amrinone","approvalYear":"1984","relationship":"same-class"},{"drugId":"milrinone","brandName":"milrinone","genericName":"milrinone","approvalYear":"1987","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"63X7MBT2LQ","CHEBI":"CHEBI:50095","INN_ID":"5288","UMLSCUI":"C0012054","ChEMBL_ID":"CHEMBL485980","KEGG_DRUG":"D01238","DRUGBANK_ID":"DB13242","PUBCHEM_CID":"9687","IUPHAR_LIGAND_ID":"5485","SECONDARY_CAS_RN":"16980-89-5","MESH_DESCRIPTOR_UI":"D003994"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":31,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C01CE04","allCodes":["C01CE04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Apr","pmid":"41763362","title":"Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment.","journal":"Virus research"},{"date":"2024 Sep","pmid":"39111545","title":"Screening of novel disease genes of sepsis-induced myocardial Disfunction by RNA sequencing and bioinformatics analysis.","journal":"Genomics"},{"date":"2024 Jun","pmid":"38734364","title":"End-ischemic pharmacological cocktail treatment to mitigate rewarming/reperfusion injury.","journal":"Cryobiology"},{"date":"2024 May 25","pmid":"38556323","title":"Effects of glucagon-like peptide-1 receptor agonists on spermatogenesis-related gene expression in mouse testis and testis-derived cell lines.","journal":"The Journal of veterinary medical science"},{"date":"2024 Feb","pmid":"38312248","title":"Successful treatment of ulceration in hidradenitis suppurativa with topical bucladesine: A case report.","journal":"Skin health and disease"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dbcamp (BUCLADESINE) is a small molecule drug in the bucladesine class, originally developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are unknown, but it is believed to work by increasing the levels of cyclic AMP (cAMP) in the body, which can help to relax smooth muscle and improve blood flow. The commercial status of Dbcamp is unclear, and it is not known whether it is FDA-approved or off-patent. Further research is needed to determine its potential uses and safety profile.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:12.470478+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}