{"id":"bucain-fentanyl","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Local site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bucain works by inhibiting sodium influx in nerve fibers, preventing action potential propagation and blocking pain signal transmission at the site of administration. Fentanyl acts as a mu-opioid receptor agonist in the central nervous system, enhancing pain relief through opioid pathways. This combination provides both local and systemic analgesia for pain management.","oneSentence":"Bucain is a local anesthetic that blocks sodium channels, while fentanyl is an opioid agonist that binds mu receptors; together they provide combined local anesthesia and systemic analgesia.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:40:15.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia with systemic analgesia for surgical and procedural pain management"}]},"trialDetails":[{"nctId":"NCT02445599","phase":"PHASE4","title":"Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain","status":"COMPLETED","sponsor":"University of Debrecen","startDate":"2014-04","conditions":"Pain, Inadequate or Impaired Respiratory Function","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"bucain + fentanyl","genericName":"bucain + fentanyl","companyName":"University of Debrecen","companyId":"university-of-debrecen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bucain is a local anesthetic that blocks sodium channels, while fentanyl is an opioid agonist that binds mu receptors; together they provide combined local anesthesia and systemic analgesia. Used for Local anesthesia with systemic analgesia for surgical and procedural pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}