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It has been studied in combination with conventional surgery and laboratory biomarker analysis in these trials.","brandName":"Bromodeoxyuridine","ecosystem":[],"mechanism":{"target":"Thymidine kinase, cytosolic, Thymidylate kinase","targets":[{"gene":"TK1","source":"DrugCentral","target":"Thymidine kinase, cytosolic","protein":"Thymidine kinase, cytosolic"}],"modality":"Small Molecule","drugClass":"broxuridine","explanation":"Imagine your body's cells are like factories that build new DNA. Bromodeoxyuridine is a fake building block that gets in the way of the factory's machinery, preventing the virus from making more copies of itself. This can help slow down or stop the spread of the virus.","oneSentence":"Bromodeoxyuridine works by mimicking the structure of thymidine, a building block of DNA, and inhibiting the action of thymidine kinase, an enzyme essential for viral DNA replication.","technicalDetail":"Bromodeoxyuridine is a nucleoside analog that competitively inhibits thymidine kinase, the enzyme responsible for phosphorylating thymidine into thymidine triphosphate, a necessary step for viral DNA replication."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Bromodeoxyuridine","title":"Bromodeoxyuridine","extract":"Bromodeoxyuridine is a synthetic nucleoside analogue with a chemical structure similar to thymidine. BrdU is commonly used to study cell proliferation in living tissues and has been studied as a radiosensitizer and diagnostic tool in people with cancer."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3042","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BROXURIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BROXURIDINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Bromodeoxyuridine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:04:12.831724","biosimilars":[],"competitors":[{"drugName":"idoxuridine","drugSlug":"idoxuridine","fdaApproval":"1963-06-11","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"zidovudine","drugSlug":"zidovudine","fdaApproval":"1987-03-19","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"broxuridine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"idoxuridine","brandName":"idoxuridine","genericName":"idoxuridine","approvalYear":"1963","relationship":"same-target"},{"drugId":"zidovudine","brandName":"zidovudine","genericName":"zidovudine","approvalYear":"1987","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT00003405","phase":"PHASE2","title":"Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"1998-04","conditions":["Leukemia"],"enrollment":0,"completionDate":"1999-04"},{"nctId":"NCT04363190","phase":"","title":"Genomic Instability in Vascular Surgeons","status":"COMPLETED","sponsor":"Hospital Clínico Universitario de Valladolid","startDate":"2018-11-09","conditions":["Cytogenetic Abnormality","Radiation Exposure"],"enrollment":28,"completionDate":"2019-11-05"},{"nctId":"NCT00001650","phase":"","title":"Use of Bromodeoxyuridine to Study White Blood Cell Replication and Survival in HIV-Infected Patients","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"1997-09-19","conditions":["HIV Infection","Acquired Immunodeficiency Syndrome"],"enrollment":56,"completionDate":"2011-05-13"},{"nctId":"NCT00003832","phase":"PHASE2","title":"Broxuridine Plus Surgery in Treating Patients With Stage I or Stage II Prostate Cancer","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"1999-07","conditions":["Stage I Prostate Cancer","Stage IIA Prostate Cancer","Stage IIB Prostate Cancer"],"enrollment":75,"completionDate":""},{"nctId":"NCT00042250","phase":"NA","title":"IUdR/BUdR Cell Cycle Labelling","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"1992-05","conditions":["Hematologic Malignancies"],"enrollment":28,"completionDate":"2002-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"G34N38R2N1","CHEBI":"CHEBI:472552","INN_ID":"3462","UMLSCUI":"C0006233","ChEMBL_ID":"CHEMBL222280","KEGG_DRUG":"D01763","DRUGBANK_ID":"DB12028","PDB_CHEM_ID":"U33","PUBCHEM_CID":"6035","MESH_DESCRIPTOR_UI":"D001973"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}