{"id":"brompheniramine-phenylephrine","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Drowsiness/sedation"},{"rate":"5-15","effect":"Dry mouth"},{"rate":"5-10","effect":"Nervousness/excitability"},{"rate":"5-10","effect":"Headache"},{"rate":"2-5","effect":"Tachycardia"},{"rate":"3-8","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200961","moleculeType":"Small molecule","molecularWeight":"435.32"},"_dailymed":{"setId":"397fe51d-b548-4fbb-8246-5f7c3ae80e97","title":"GOOD SENSE CHILDRENS COLD AND COUGH (BROMPHENIRAMINE MALEATE, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL) SOLUTION [PREFERRED PHARMACEUTICALS INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Brompheniramine is a first-generation antihistamine that crosses the blood-brain barrier and competitively antagonizes H1 receptors, reducing histamine-mediated allergic responses including itching, sneezing, and urticaria. Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction of nasal blood vessels, reducing mucosal edema and nasal congestion. Together, they provide symptomatic relief of allergic rhinitis and upper respiratory congestion.","oneSentence":"Brompheniramine blocks histamine H1 receptors to reduce allergic symptoms, while phenylephrine acts as an alpha-1 adrenergic agonist to constrict blood vessels and reduce nasal congestion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:51.432Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis with nasal congestion"},{"name":"Urticaria and pruritus associated with allergic reactions"},{"name":"Upper respiratory allergy symptoms"}]},"trialDetails":[{"nctId":"NCT01393548","phase":"PHASE3","title":"Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis","status":"COMPLETED","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2014-08","conditions":"Nasal Congestion and Inflammations, Rhinitis","enrollment":879},{"nctId":"NCT01393561","phase":"PHASE3","title":"Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis","status":"COMPLETED","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2014-07","conditions":"Nasal Congestion and Inflammations, Rhinitis","enrollment":167}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"DEHYDRATION"},{"count":3,"reaction":"DIARRHOEA"},{"count":2,"reaction":"ACUTE KIDNEY INJURY"},{"count":2,"reaction":"CLOSTRIDIUM DIFFICILE INFECTION"},{"count":2,"reaction":"HYPOVOLAEMIA"},{"count":2,"reaction":"MUCOSAL INFLAMMATION"},{"count":2,"reaction":"MUSCLE SPASMS"},{"count":2,"reaction":"PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME"},{"count":2,"reaction":"PALPITATIONS"},{"count":1,"reaction":"ACCIDENTAL DRUG INTAKE BY CHILD"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Group 1"],"phase":"marketed","status":"active","brandName":"brompheniramine + phenylephrine","genericName":"brompheniramine + phenylephrine","companyName":"Ache Laboratorios Farmaceuticos S.A.","companyId":"ache-laboratorios-farmaceuticos-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brompheniramine blocks histamine H1 receptors to reduce allergic symptoms, while phenylephrine acts as an alpha-1 adrenergic agonist to constrict blood vessels and reduce nasal congestion. Used for Allergic rhinitis with nasal congestion, Urticaria and pruritus associated with allergic reactions, Upper respiratory allergy symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}