{"id":"broad-area-ala-2-hour-incubation","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":{"chemblId":"CHEMBL263781","moleculeType":"Protein","molecularWeight":"1410.61"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism is based on the principle that abnormal cells, such as those found in actinic keratoses, will accumulate more porphyrins than normal cells. When exposed to blue light, these porphyrins become excited and release energy as heat, damaging the abnormal cells.","oneSentence":"ALA (5-aminolevulinic acid) is a precursor to porphyrins, which accumulate in abnormal cells and become fluorescent under blue light, allowing for photodynamic therapy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:57:56.629Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"}]},"trialDetails":[{"nctId":"NCT01475955","phase":"PHASE2","title":"Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)","status":"COMPLETED","sponsor":"DUSA Pharmaceuticals, Inc.","startDate":"2011-12","conditions":"Actinic Keratosis","enrollment":235}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Levulan"],"phase":"phase_2","status":"active","brandName":"Broad Area ALA 2 hour incubation","genericName":"Broad Area ALA 2 hour incubation","companyName":"DUSA Pharmaceuticals, Inc.","companyId":"dusa-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ALA (5-aminolevulinic acid) is a precursor to porphyrins, which accumulate in abnormal cells and become fluorescent under blue light, allowing for photodynamic therapy. Used for Actinic keratosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}