{"id":"brivudine","rwe":[],"tags":[{"label":"brivudine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Thymidine kinase, cytosolic","category":"target"},{"label":"TK1","category":"gene"},{"label":"J05AB15","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiviral Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":177.771,"date":"","count":44,"signal":"Labelled drug-drug interaction medication error","source":"DrugCentral FAERS","actionTaken":"Reported 44 times (LLR=178)"},{"llr":89.978,"date":"","count":34,"signal":"Mucosal inflammation","source":"DrugCentral FAERS","actionTaken":"Reported 34 times (LLR=90)"},{"llr":84.168,"date":"","count":54,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 54 times (LLR=84)"},{"llr":77.908,"date":"","count":13,"signal":"Pharyngeal inflammation","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=78)"},{"llr":75.202,"date":"","count":37,"signal":"Pancytopenia","source":"DrugCentral FAERS","actionTaken":"Reported 37 times (LLR=75)"},{"llr":65.221,"date":"","count":20,"signal":"Oesophagitis","source":"DrugCentral FAERS","actionTaken":"Reported 20 times (LLR=65)"},{"llr":62.169,"date":"","count":7,"signal":"Rash maculovesicular","source":"DrugCentral FAERS","actionTaken":"Reported 7 times (LLR=62)"}],"commonSideEffects":[{"effect":"Labelled drug-drug interaction medication error","drugRate":"LLR 178","severity":"common"},{"effect":"Mucosal inflammation","drugRate":"LLR 90","severity":"common"},{"effect":"Pharyngeal inflammation","drugRate":"LLR 78","severity":"common"},{"effect":"Pancytopenia","drugRate":"LLR 75","severity":"common"},{"effect":"Oesophagitis","drugRate":"LLR 65","severity":"common"},{"effect":"Rash maculovesicular","drugRate":"LLR 62","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"brivudin","offLabel":[],"synonyms":["brivudine","brivudin","bromovinyldeoxyuridine"],"timeline":[],"aiSummary":"Brivudin, also known as brivudine phosphoramidate, is a medication used to treat Herpes Zoster and has been studied in clinical trials for its potential use in treating Colorectal Cancer.","brandName":"Brivudin","ecosystem":[],"mechanism":{"target":"Thymidine kinase, cytosolic, Thymidine kinase","targets":[{"gene":"TK1","source":"DrugCentral","target":"Thymidine kinase, cytosolic","protein":"Thymidine kinase, cytosolic"}],"modality":"Small Molecule","drugClass":"brivudine","explanation":"Imagine your body's cells are like factories that build new parts. Brivudin is like a faulty part that gets inserted into the viral DNA, causing the factory to stop working properly and preventing the virus from making more copies of itself.","oneSentence":"Brivudin works by mimicking the structure of a nucleoside, which is then incorporated into viral DNA, causing chain termination and preventing viral replication.","technicalDetail":"Brivudin is a nucleoside analog that acts as a competitive inhibitor of thymidine kinase, the enzyme responsible for phosphorylating thymidine into its active form. By inhibiting this enzyme, Brivudin prevents the incorporation of thymidine into viral DNA, leading to chain termination and ultimately, viral replication inhibition."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/397","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BRIVUDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BRIVUDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:03:14.361124","biosimilars":[],"competitors":[{"drugName":"acyclovir","drugSlug":"acyclovir","fdaApproval":"1982-03-29","patentExpiry":"Mar 23, 2027","patentStatus":"Patent 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protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"brivudine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acyclovir","brandName":"acyclovir","genericName":"acyclovir","approvalYear":"1982","relationship":"same-class"},{"drugId":"idoxuridine","brandName":"idoxuridine","genericName":"idoxuridine","approvalYear":"1963","relationship":"same-class"},{"drugId":"vidarabine","brandName":"vidarabine","genericName":"vidarabine","approvalYear":"1976","relationship":"same-class"},{"drugId":"ganciclovir","brandName":"ganciclovir","genericName":"ganciclovir","approvalYear":"1989","relationship":"same-class"},{"drugId":"famciclovir","brandName":"famciclovir","genericName":"famciclovir","approvalYear":"1994","relationship":"same-class"},{"drugId":"valaciclovir","brandName":"valaciclovir","genericName":"valaciclovir","approvalYear":"1995","relationship":"same-class"},{"drugId":"cidofovir","brandName":"cidofovir","genericName":"cidofovir","approvalYear":"1996","relationship":"same-class"},{"drugId":"penciclovir","brandName":"penciclovir","genericName":"penciclovir","approvalYear":"1996","relationship":"same-class"},{"drugId":"valganciclovir","brandName":"valganciclovir","genericName":"valganciclovir","approvalYear":"2001","relationship":"same-class"},{"drugId":"remdesivir","brandName":"remdesivir","genericName":"remdesivir","approvalYear":"2020","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07099157","phase":"PHASE4","title":"Efficacy and Safety of Brivudine in the Treatment of Herpes Zoster","status":"RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-08-25","conditions":["Herpes Zoster"],"enrollment":140,"completionDate":"2027-12-31"},{"nctId":"NCT00031616","phase":"PHASE1,PHASE2","title":"NB1011 in Treating Patients With Metastatic or Recurrent Colorectal Cancer","status":"UNKNOWN","sponsor":"NewBiotics","startDate":"2001-12","conditions":["Colorectal Cancer"],"enrollment":0,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006752","UNII":"2M3055079H","INN_ID":"6267","RXNORM":"59161","UMLSCUI":"C0163272","ChEMBL_ID":"CHEMBL31634","KEGG_DRUG":"D07249","DRUGBANK_ID":"DB03312","PDB_CHEM_ID":"BVD","PUBCHEM_CID":"446727","SNOMEDCT_US":"698049003","MESH_SUPPLEMENTAL_RECORD_UI":"C020235"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":83,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J05AB15","allCodes":["J05AB15"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}