{"id":"brimonidine-topical-gel-0-33-soc","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema (rebound redness)"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Pallor"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Brimonidine selectively binds to alpha-2 adrenergic receptors on vascular smooth muscle cells, causing vasoconstriction that reduces blood flow to the treated area. This mechanism decreases the appearance of facial erythema (redness) associated with conditions like rosacea. The gel formulation allows for localized topical delivery with minimal systemic absorption.","oneSentence":"Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness when applied topically to the skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:32:22.668Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Persistent facial erythema associated with rosacea"}]},"trialDetails":[{"nctId":"NCT03048058","phase":"PHASE4","title":"Internet Surveys and Their Impact on Adherence for Rosacea","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2016-05-05","conditions":"Rosacea","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mirvaso"],"phase":"marketed","status":"active","brandName":"brimonidine topical gel 0.33% & SOC","genericName":"brimonidine topical gel 0.33% & SOC","companyName":"Wake Forest University Health Sciences","companyId":"wake-forest-university-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness when applied topically to the skin. Used for Persistent facial erythema associated with rosacea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}