{"id":"brimonidine-timolol-mixed-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular hyperemia"},{"rate":null,"effect":"Dry eye"},{"rate":null,"effect":"Allergic conjunctivitis"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Brimonidine stimulates alpha-2 adrenergic receptors to decrease aqueous humor production and increase uveoscleral outflow. Timolol blocks beta-adrenergic receptors to reduce aqueous humor production. The combination provides additive IOP-lowering effects through complementary mechanisms.","oneSentence":"Brimonidine is an alpha-2 adrenergic agonist and timolol is a non-selective beta-blocker; together they reduce intraocular pressure through different pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:46.931Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT01446497","phase":"PHASE4","title":"Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2010-10","conditions":"Normal Tension Glaucoma","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Combigan"],"phase":"marketed","status":"active","brandName":"Brimonidine/Timolol mixed combination","genericName":"Brimonidine/Timolol mixed combination","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brimonidine is an alpha-2 adrenergic agonist and timolol is a non-selective beta-blocker; together they reduce intraocular pressure through different pathways. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}