{"id":"brimonidine-0-33-gel-br","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema (localized redness)"},{"rate":null,"effect":"Skin irritation or burning"},{"rate":null,"effect":"Pruritus (itching)"},{"rate":null,"effect":"Pallor (whitening of skin)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Brimonidine selectively binds to alpha-2 adrenergic receptors on vascular smooth muscle cells, causing vasoconstriction that reduces blood flow to the skin surface. This topical gel formulation is applied directly to facial erythema (redness), where it decreases visible flushing and persistent redness by narrowing capillaries in the affected areas. The effect is temporary and localized to the application site.","oneSentence":"Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:21:42.074Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Persistent facial erythema associated with rosacea"}]},"trialDetails":[{"nctId":"NCT02616250","phase":"PHASE4","title":"MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea.","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-12","conditions":"Rosacea","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Brimonidine 0.33% gel (Br)","genericName":"Brimonidine 0.33% gel (Br)","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness in the skin. Used for Persistent facial erythema associated with rosacea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}