{"id":"brilliant-green","rwe":[{"pmid":"41865704","year":"2026","title":"Zr-modified TiO₂ nanocomposites with enhanced visible-light photocatalytic and photobiological performance.","finding":"","journal":"Journal of photochemistry and photobiology. B, Biology","studyType":"Clinical Study"},{"pmid":"41767223","year":"2026","title":"Valorisation of banana stem into N-doped activated carbon as a selective sorbent for cationic dyes and pharmaceutical contaminants.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41762880","year":"2026","title":"Green air-assisted LLME using a novel hydrophobic deep eutectic solvent for the extraction and quantification of Brilliant Green and Rhodamine B in food matrices.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"41624946","year":"2026","title":"Brilliant green dye adsorption from aquatic medium using an activated carbon/graphene/polyacryl amide composite as a novel effective adsorbent: experimental investigation and factorial design optimization.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41496822","year":"2026","title":"Repurposing waste plastic into a sustainable adsorbent for removing synthetic dye: experimental, optimization and theoretical modeling.","finding":"","journal":"RSC advances","studyType":"Clinical Study"}],"tags":[{"label":"brilliant green","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Solution","category":"form"},{"label":"Swab","category":"form"},{"label":"Active","category":"status"},{"label":"Infection protection","category":"indication"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Coloring Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Aphthous ulcer of mouth","Vaginal irritation"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=brilliant green","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:56:44.389325+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:56:56.174776+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=brilliant green","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:56:56.927233+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1790039/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:56:57.408012+00:00"}},"allNames":["brilliant green"],"offLabel":[],"synonyms":["brilliant green"],"timeline":[],"ecosystem":[{"indication":"Infection protection","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"brilliant green","explanation":"","oneSentence":"","technicalDetail":"Brilliant Green exerts its antimicrobial effects by binding to and disrupting the bacterial cell membrane, ultimately leading to cell lysis and death. This action is thought to be mediated through the disruption of membrane integrity and the inhibition of essential cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4665","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=brilliant%20green","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=brilliant green","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:06:25.230096","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:56:59.288174+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"brilliant green","indications":{"approved":[{"name":"Infection protection","source":"DrugCentral","snomedId":386335003,"regulator":"FDA","eligibility":"Newborns"}],"offLabel":[{"name":"Candidiasis of skin","source":"DrugCentral","drugName":"brilliant green","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT01485575","phase":"","title":"Mechanical Properties of the Internal Limiting Membrane and Intraoperative Utility of Brilliant Blue g (Bbg) and Indocyanine Green (Icg) Assisted Chromovitrectomy","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2011-11","conditions":["Macular Edema"],"enrollment":50,"completionDate":"2028-06"},{"nctId":"NCT05982028","phase":"NA","title":"Patients' Quality of Life After Pilonidal Cyst Operations.","status":"UNKNOWN","sponsor":"Lithuanian University of Health Sciences","startDate":"2020-09-01","conditions":["Pilonidal Cyst","Pain Postoperative","Quality of Life"],"enrollment":100,"completionDate":"2025-03-01"},{"nctId":"NCT05715983","phase":"NA","title":"Comparison of Laser Destruction of Pilonidal Sinus Disease (SILAC) and Bascom II Procedure.","status":"UNKNOWN","sponsor":"Russian Society of Colorectal Surgeons","startDate":"2022-12-08","conditions":["Pilonidal Disease"],"enrollment":164,"completionDate":"2025-01-31"},{"nctId":"NCT03946267","phase":"NA","title":"Infracyanine Green vs Brilliant Blue G in Macular Hole Inverted Flap Surgery: A Swept Source OCT Analysis.","status":"COMPLETED","sponsor":"Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo","startDate":"2018-01-09","conditions":["Macular Holes"],"enrollment":43,"completionDate":"2018-08-23"},{"nctId":"NCT00757471","phase":"NA","title":"Brillant Blue Versus Indocyanine Green for Macular Hole Surgery","status":"COMPLETED","sponsor":"The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery","startDate":"2008-08","conditions":["Idiopathic Macular Holes"],"enrollment":60,"completionDate":"2015-08"},{"nctId":"NCT01083004","phase":"PHASE3","title":"Brilliant Blue Versus Indocyanine Green","status":"UNKNOWN","sponsor":"University of Cologne","startDate":"2008-01","conditions":["Macular Pucker","Macular Hole","Vitreoretinal Surgery"],"enrollment":50,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Solution, Swab","formulations":[{"form":"SOLUTION","route":"TOPICAL","productName":"Perineze Triple Dye"},{"form":"SWAB","route":"TOPICAL","productName":"Kerr 100 Triple Dye Dispos-A"}]},"crossReferences":{"NUI":"N0000179055","MMSL":"11833","NDDF":"002615","UNII":"G0L543D370","VUID":"4018857","VANDF":"4018857","RXNORM":"19698","UMLSCUI":"C0054053","chemblId":"CHEMBL1790039","ChEMBL_ID":"CHEMBL1181633","DRUGBANK_ID":"DB11279","PUBCHEM_CID":"12449","SNOMEDCT_US":"396057002","MESH_SUPPLEMENTAL_RECORD_UI":"C006798"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":814,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 18","pmid":"41865704","title":"Zr-modified TiO₂ nanocomposites with enhanced visible-light photocatalytic and photobiological performance.","journal":"Journal of photochemistry and photobiology. B, Biology"},{"date":"2026 Feb 26","pmid":"41767223","title":"Valorisation of banana stem into N-doped activated carbon as a selective sorbent for cationic dyes and pharmaceutical contaminants.","journal":"RSC advances"},{"date":"2026 Feb 26","pmid":"41762880","title":"Green air-assisted LLME using a novel hydrophobic deep eutectic solvent for the extraction and quantification of Brilliant Green and Rhodamine B in food matrices.","journal":"Food chemistry"},{"date":"2026 Jan 26","pmid":"41624946","title":"Brilliant green dye adsorption from aquatic medium using an activated carbon/graphene/polyacryl amide composite as a novel effective adsorbent: experimental investigation and factorial design optimization.","journal":"RSC advances"},{"date":"2026 Jan 2","pmid":"41496822","title":"Repurposing waste plastic into a sustainable adsorbent for removing synthetic dye: experimental, optimization and theoretical modeling.","journal":"RSC advances"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"brilliant green","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:56:59.288174+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}