{"id":"brexanolone-injection-zulresso","safety":{"commonSideEffects":[{"rate":"~60%","effect":"Sedation"},{"rate":"~30%","effect":"Dizziness"},{"rate":"~25%","effect":"Somnolence"},{"rate":"~15%","effect":"Headache"},{"rate":"~5%","effect":"Syncope"},{"rate":"~2%","effect":"Loss of consciousness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Brexanolone is the synthetic form of allopregnanolone, an endogenous neurosteroid metabolite of progesterone. It binds to and potentiates GABA-A receptors, increasing chloride channel conductance and neuronal hyperpolarization, thereby enhancing GABAergic inhibitory signaling. This mechanism is thought to restore neurochemical balance in postpartum depression, where allopregnanolone levels are dysregulated.","oneSentence":"Brexanolone is a synthetic neuroactive steroid that acts as a positive allosteric modulator of GABA-A receptors to enhance inhibitory neurotransmission in the brain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:49.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postpartum depression in adult women"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zulresso"],"phase":"marketed","status":"active","brandName":"Brexanolone Injection [Zulresso]","genericName":"Brexanolone Injection [Zulresso]","companyName":"Donald Jeffrey Newport","companyId":"donald-jeffrey-newport","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brexanolone is a synthetic neuroactive steroid that acts as a positive allosteric modulator of GABA-A receptors to enhance inhibitory neurotransmission in the brain. Used for Postpartum depression in adult women.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}