{"id":"bremen-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL5940488","moleculeType":null,"molecularWeight":"498.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BREMEN is a preservative-free artificial tear solution intended for topical ocular use. It works by providing lubrication to the cornea and conjunctiva, reducing friction and irritation associated with dry eye syndrome. The formulation aims to stabilize the tear film and protect the ocular surface from further damage.","oneSentence":"BREMEN eye drops is a topical ophthalmic formulation designed to treat dry eye disease by lubricating and protecting the ocular surface.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:44:32.626Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT03235232","phase":"PHASE3","title":"BREMEN Eye Drops Versus Combigan for Open-angle Glaucoma or Intraocular Hypertension","status":"COMPLETED","sponsor":"EMS","startDate":"2021-02-01","conditions":"Ocular Hypertension, Primary Open-angle Glaucoma","enrollment":406}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BREMEN eye drops","genericName":"BREMEN eye drops","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BREMEN eye drops are used to treat Ocular Hypertension and Primary Open-angle Glaucoma, as indicated by ClinicalTrials.gov. The mechanism of action of BREMEN eye drops is not specified in the provided facts, but it is being compared to Combigan, which is a combination of brimonidine and timolol, suggesting it may have a similar mechanism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}