{"id":"brand-name-metoprolol-er","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5","effect":"Depression"},{"rate":"5-10","effect":"Sexual dysfunction"},{"rate":"1-5","effect":"Bronchospasm (in susceptible patients)"}]},"_chembl":{"chemblId":"CHEMBL2356097","moleculeType":"Small molecule","molecularWeight":"652.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metoprolol selectively blocks beta-1 adrenergic receptors on cardiac tissue, decreasing heart contractility and heart rate. This reduces myocardial oxygen demand and lowers blood pressure. The extended-release formulation provides sustained drug delivery over 24 hours, allowing once-daily dosing for improved patient compliance in chronic cardiovascular conditions.","oneSentence":"Metoprolol ER is a beta-1 selective adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of norepinephrine and epinephrine on the heart.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:36.461Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Myocardial infarction (post-MI management)"},{"name":"Heart failure"},{"name":"Atrial fibrillation (rate control)"}]},"trialDetails":[{"nctId":"NCT02417246","phase":"PHASE4","title":"Open-Labeled PK-PD Studies of Metoprolol ER","status":"COMPLETED","sponsor":"University of Florida","startDate":"2015-08","conditions":"Blood Pressure","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Metoprolol extended-release (ER)"],"phase":"marketed","status":"active","brandName":"brand name metoprolol ER","genericName":"brand name metoprolol ER","companyName":"University of Florida","companyId":"university-of-florida","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoprolol ER is a beta-1 selective adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of norepinephrine and epinephrine on the heart. Used for Hypertension, Angina pectoris, Myocardial infarction (post-MI management).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}