{"id":"br1019a-1","safety":{"commonSideEffects":[{"rate":"null","effect":"Cough"},{"rate":"null","effect":"Dizziness"},{"rate":"null","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3301587","moleculeType":"Antibody"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"BR1019A-1 works by inhibiting the angiotensin-converting enzyme (ACE), which is a key component of the renin-angiotensin system. This leads to a decrease in angiotensin II levels, resulting in vasodilation and a reduction in blood pressure.","oneSentence":"BR1019A-1 is a small molecule that targets the renin-angiotensin system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:43:04.078Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT06220773","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of BR1019A and BR1019B Combination Therapy","status":"RECRUITING","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2024-05-21","conditions":"Essential Hypertension, Type 2 Diabetes Mellitus","enrollment":276}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BR1019A-1","genericName":"BR1019A-1","companyName":"Boryung Pharmaceutical Co., Ltd","companyId":"boryung-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BR1019A is a programmed cell death 1 ligand 1 inhibitor, classified as an antibody inhibitor. It is being studied in clinical trials for the treatment of Essential Hypertension and Type 2 Diabetes Mellitus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}